谷胱甘肽过氧化酶4及铁蛋白重链1在甲状腺乳头状癌组织中的表达  

Expression of GPX-4 and FTH-1 in papillary thyroid cancer tissue

作　　者：史多琦 范育林 张思东[1] 曹寅[2] SHI Duoqi;FAN Yulin;ZHANG Sidong;CAO Yin(Department of General Surgery,Hefei Third People's Hospital,Hefei,Anhui 230022,China;Office of the Academy of Sciences,Anhui University of Traditional Chinese Medicine,Hefei,Anhui 230012,China)

机构地区：[1]合肥市第三人民医院普外科,安徽合肥230022 [2]安徽中医药大学科学院办公室,安徽合肥230012

出　　处：《安徽医药》2024年第8期1578-1581,I0002,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨甲状腺乳头状癌(PTC)组织中谷胱甘肽过氧化酶4(GPX-4)和铁蛋白重链1(FTH-1)的表达情况,分析二者在PTC发生发展中的生物学意义。方法采集2019年6月至2023年8月合肥市第三人民医院40例PTC病人的手术切除标本,分别为癌组织和癌旁组织。应用免疫组织化学染色检测PTC组织和癌旁组织中GPX-4和FTH-1的表达情况,然后利用SPSS 22.0软件进行统计分析。结果GPX-4在PTC组织与癌旁组织中的阳性表达率分别为80.00%(32/40)和15.00%(6/40),GPX-4在癌组织中的阳性表达率显著高于癌旁组织,差异有统计学意义(χ^(2)=18.38,P<0.001)。同样,FTH-1在PTC组织和癌旁组织中的阳性表达率分别为72.50%(29/40)和10.00%(4/40),FTH-1在癌组织中的阳性表达率也显著高于癌旁组织,差异有统计学意义(χ^(2)=18.58,P<0.001)。GPX-4和FTH-1在PTC组织中的表达与PTC的TNM分期及淋巴结转移具有相关性(P<0.05)。结论GPX-4和FTH-1在PTC组织中均呈阳性高表达,与PTC的TNM分期和淋巴结转移有关,提示其与PTC的发生发展密切相关,二者检测可作为评估PTC临床预后的辅助指标,也为PTC的分子靶向治疗提供新的方向。Objective To study the levels of GPX-4 and FTH-1 in papillary thyroid carcinoma(PTC)tissues and examine their roles in the initiation and progression of PTC.Methods Surgical resection specimens were collected from 40 patients with PTC in Hefei Third People's Hospital from June 2019 to August 2023,including cancer tissue and adjacent tissue.Immunohistochemical staining was utilized to identify the presence of GPX-4 and FTH-1 in both PTC tissue and adjacent tissues,and statistical analysis was performed using SPSS 22.0 software.Results The positive expression rate of GPX-4 in papillary thyroid carcinoma(PTC)tissues and adjacent tissues was 80.00%(32/40)and 15.00%(6/40),respectively,and positive expression rate of GPX-4 in cancer tissues was significantly higher than that in the adjacent tissues,and the difference between the two was statistically significant(χ^(2)=18.38,P<0.001).Likewise,the positive rate of FTH-1 in PTC tissue and adjacent tissues was 72.50%(29/40)and 10.00%(4/40),respectively.The rate of FTH-1 positive expression in cancer tissue was notably higher than that in adjacent tissues,with a statistically significant difference(χ^(2)=18.58,P<0.001).The expression of GPX-4 and FTH-1 in PTC tissue is correlated with TNM staging and lymph node metastasis of PTC(P<0.05).Conclusions Both GPX-4 and FTH-1 are highly expressed in PTC tissues,which are related to the TNM staging and lymph node metastasis of PTC,suggesting their close correlation with the occurrence and development of PTC.The detection of both markers can serve as auxiliary indicators for evaluating the clinical prognosis of PTC and provide new directions for molecular targeted therapy of PTC.

关 键 词：甲状腺肿瘤 谷胱甘肽过氧化酶4 铁蛋白重链1 免疫组化 铁死亡 

分 类 号：R736.1[医药卫生—肿瘤]