软肝化坚颗粒联合生物信息红外肝病治疗仪对慢性乙型肝炎病人抗肝纤维化疗效观察  

Ruangganhuajian granule combined with biological information infrared liver disease therapeutic instrument clinical observation of anti-liver fibrosis in patients with chronic hepatitis B

作　　者：史蕾 王洋 孟雪 郑浩杰[1] SHI Lei;WANG Yang;MENG Xue;ZHENG Haojie(Department of Infection,The Fifth Hospital of Shijiazhuang,Shijiazhuang,Hebei 050200,China)

机构地区：[1]石家庄市第五医院感染一科,河北石家庄050200

出　　处：《安徽医药》2024年第8期1599-1603,共5页Anhui Medical and Pharmaceutical Journal

基　　金：河北省中医药管理局科研计划项目(2014089)。

摘　　要：目的探究软肝化坚颗粒联合生物信息红外肝病治疗仪对慢性乙型肝炎(CHB)病人抗肝纤维化的疗效。方法选取2015年2月至2018年5月石家庄市第五医院收治的CHB病人120例,分为对照组(60例)和观察组(60例),对照组采用生物信息红外肝病治疗仪治疗,观察组在对照组基础上联合软肝化坚颗粒。记录两组临床疗效、血清肝纤维化指标[透明质酸(HA)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(Ⅳ-C)、层黏连蛋白(LN)],肝功能指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBiL)]、中医症候积分以及不良反应发生情况。结果治疗后,观察组总有效率(90.00%)高于对照组(72.50%)(P<0.05);观察组血清HA、LN、PC-Ⅲ、Ⅳ-C水平均低于对照组[(93.34±36.62)mg/L比(110.87±35.71)mg/L、(73.78±24.14)mg/L比(85.31±25.62)mg/L、(84.72±23.75)mg/L比(100.92±23.34)mg/L、(56.78±14.14)mg/L比(77.47±15.22)mg/L](P<0.05);观察组ALT、AST、GGT及中医证候积分低于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论CHB病人采用软肝化坚颗粒联合生物信息红外肝病治疗仪治疗,可有效缓解病人肝纤维化,改善肝功能,安全性高。Objective To explore the effect of Ruanganhuajian granule combined with biological information infrared liver disease treatment instrument on anti-liver fibrosis in patients with chronic hepatitis B.Methods A total of 120 patients with CHB admitted to The Fifth Hospital of Shijiazhuang from February 2015 to May 2018.They were selected and divided into the observation group(60 cases)and the control group(60 cases).the control group was treated with biological information infrared liver disease treatment instrument,and the observation group was combined with Ruganhuajian granule on the basis of the control group.Record two groups of clinical curative effect,serum liver fibrosis indexes[hyaluronic acid(HA),typeⅢbefore collagen(PC-Ⅲ),collagen typeⅣ(Ⅳ-C)laminin(LN)],liver function index[alanine aminotransferase(ALT),aspertate aminotransferase(AST),total bilirubin(TBiL)].Two sets of TCM syndrome scores and adverse reactions were recorded.Results After treatment,The total effective rate in the observation group(90.00%)was higher than that in the control group(72.50%)(P<0.05).The serum levels of HA,LN,PC-ⅢandⅣ-C in the observation group were lower than those in the control group[(93.34±36.62)mg/L vs.(110.87±35.71)mg/L,(73.78±24.14)mg/L vs.(85.31±25.62)mg/L,(84.72±23.75)mg/L vs.(100.92±23.34)mg/L,(56.78±14.14)mg/L vs.(77.47±15.22)mg/L](P<0.05).The scores of ALT,AST,GGT and TCM syndromes in the observation group were lower(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ruanganhuajian granule combined with biological information infrared liver disease treatment instrument for CHB patients can effectively alleviate liver fibrosis and improve liver function,with high safety.

关 键 词：乙型肝炎 慢性 软肝化坚颗粒 生物信息红外肝病治疗仪 肝纤维化 

分 类 号：R575.2[医药卫生—消化系统] R512.62[医药卫生—内科学]