六君子汤加味联合甲地孕酮治疗结肠癌手术化疗后厌食症的疗效观察  

Effect of megestrol on chemotherapy-induced anorexia in patients undergoing colon cancer surgery

作　　者：高文侠 葛小栋 王建桥 王艳 于倩 GAO Wenxia;GE Xiaodong;WANG Jianqiao;WANG Yan;YU Qian(Department of Pharmacy,Tangshan Hospital of Traditional Chinese Medicine,Tangshan,Hebei 063000,China;Department of Oncology,Tangshan Hospital of Traditional Chinese Medicine,Tangshan,Hebei 063000,China)

机构地区：[1]唐山市中医医院药学部,河北唐山063000 [2]唐山市中医医院肿瘤科,河北唐山063000

出　　处：《安徽医药》2024年第8期1659-1662,共4页Anhui Medical and Pharmaceutical Journal

基　　金：河北省中医药管理局中医药类科学研究课题计划项目(2023196)。

摘　　要：目的观察六君子汤加味联合甲地孕酮治疗结肠癌手术病人化疗后厌食症的疗效。方法选取2021年1月至2022年4月唐山市中医医院诊治的结肠癌手术化疗后厌食症病人60例作为研究对象。根据信封法随机将病人分为对照组(30例,甲地孕酮治疗)和观察组(30例,六君子汤加味联合甲地孕酮治疗)。比较两组中医症状积分、体质量和厌食评分、营养指标(白蛋白、前白蛋白)、胃肠激素(胃泌素、胃动素)水平、生活质量评分(QOL评分)以及临床疗效。结果观察组总有效率为93.33%,高于对照组的73.33%(P<0.05);治疗后观察组恶心呕吐[(1.02±0.21)分比(1.35±0.28)分]、脘腹胀满[(1.12±0.32)分比(1.47±0.35)分]、嗳气反酸[(0.89±0.22)分比(1.43±0.27)分]、脘腹疼痛[(0.95±0.23)分比(1.52±0.28)分]等中医证候积分和NRS评分均低于对照组(P<0.05);而体质量、血清白蛋白水平、血清前白蛋白水平、胃泌素水平、胃动素水平、QOL评分均高于对照组(P<0.05)。结论六君子汤加味联合甲地孕酮治疗结肠癌手术病人化疗后厌食症可减轻病人临床症状,增加食欲,增强胃肠功能、改善营养状况,提高生活质量,疗效显著。Objective To observe the efficacy of modified Liujunzi decoction combined with megestrol in the treatment of anorexia after chemotherapy in colon cancer surgery patients.Methods A total of 60 patients with anorexia after surgery and chemotherapy for colon cancer diagnosed and treated in Tangshan Hospital of Traditional Chinese Medicine from January 2021 to April 2022 were selected as the research objects.Patients were randomly assigned into control group(30 cases,megestrol treatment)and study group(30 cases,modified Liujunzi decoction combined with megestrol treatment)according to the envelope method.The TCM syndrome scores,weight and anorexia scores,nutritional indicators(albumin,prealbumin),gastrointestinal hormone levels(gastrin,motilin),quality of life scores(QOL scores),and clinical efficacy of the two groups were compared.Results The total effective rate of the study group was 93.33%,which was higher than 73.33%of the control group(P<0.05).After treatment,the TCM syndrome scores of nauseas and vomiting[(1.02±0.21)points vs.(1.35±0.28)points],abdominal distention[(1.12±0.32)points vs.(1.47±0.35)points],belching acid reflux[(0.89±0.22)points vs.(1.43±0.27)points]and abdominal pain[(0.95±0.23)points vs.(1.52±0.28)points],and NRS scores in the study group were lower than those of the control group(P<0.05),while the weights,serum albumin level,serum prealbumin level,gastrin level,motilin level and QOL score were all higher than those in the control group(P<0.05).Conclusion Modified Liujunzi decoction combined with megestrol in the treatment of anorexia after chemotherapy in colon cancer surgery patients can reduce the clinical symptoms of patients,increase appetite,enhance gastrointestinal function,improve nutritional status,improve quality of life,and have significant curative effects.

关 键 词：厌食 六君子汤 甲地孕酮 疗效 

分 类 号：R735.35[医药卫生—肿瘤]