尿液无创检测在膀胱癌诊断和复发监测中的应用现状  

Application status of non-invasive urine biopsy in diagnosis and recurrence surveillance of bladder cancer

作　　者：宋泓辰 张雨锋 吴梦华 刘佳欣 李炫昊[1] 宋健[1] 石铭俊 Song Hongchen;Zhang Yufeng;Wu Menghua;Liu Jiaxin;Li Xuanhao;Song Jian;Shi Mingjun(Department of Urology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China;Department of Urology,Beijing Youan Hospital,Capital Medical University,Beijing 100069,China;Department of Urology,Beijing Fuxing Hospital,Capital Medical University,Beijing 100045,China)

机构地区：[1]首都医科大学附属北京友谊医院泌尿外科,北京100050 [2]首都医科大学附属北京朝阳医院,北京100020 [3]首都医科大学附属北京佑安医院泌尿外科,北京100069 [4]首都医科大学附属北京复兴医院泌尿外科,北京100045

出　　处：《国际外科学杂志》2024年第6期423-432,F0004,共11页International Journal of Surgery

基　　金：国家自然科学基金面上项目(82373436);北京市医院管理中心青苗计划(QML20230114)。

摘　　要：膀胱癌是全球最常见的泌尿系统恶性肿瘤之一。尿液细胞学检查和膀胱镜检查是临床上常用于膀胱癌诊断和复发监测的重要工具,但由于其灵敏度较低、操作有创性等缺陷,临床上亟需开发新型无创、高灵敏度的检测工具。基于尿液的无创分子检测是领域内重点研究方向,极具前瞻性。本综述从应用于膀胱癌诊断和复发监测的尿液分子标志物出发,对蛋白分子类尿液分子标志物(包括NMP22、BTA和UroVysion等)以及DNA或RNA类尿液分子标志物(包括cfDNA、AssureMDx和Xpert BC Monitor等)进行综述,并对各标志物的特征以及膀胱癌诊断和复发监测中的灵敏度及特异性进行汇总,为进一步优化尿液标志物在临床中的应用提供理论与经验支持。Bladder cancer is one of the most common malignancy in the urinary system over the world.Urine cytology and cystoscopy are important tools for bladder cancer diagnosis and recurrence monitoring.However,due to the limited sensitivity and invasive procedure,there is an urgent need to develop new non-invasive and highly sensitive liquid biopsy approaches.Urine biopsy is a research focus in the field and has great potential.This review focused on protein-based urine markers(including NMP22,BTA and UroVysion etc.)and DNA or RNA-based urine markers(including cfDNA,AssureMDx and Xpert BC Monitor etc.),which were used for bladder cancer diagnosis and recurrence monitoring,and summarized the sensitivity and specificity of each biomarker as well as their characteristics in the diagnosis and recurrence surveillance of bladder cancer.This study provides theoretical and empirical support for further optimization and application of these biomarkers in clinical practice.

关 键 词：膀胱肿瘤 细胞诊断学 复发 尿液检测 分子标志物 

分 类 号：R737.14[医药卫生—肿瘤]