泛素特异性蛋白酶家族在胰腺癌中的研究进展  

Research progress of ubiquitin-specific proteases in pancreatic cancer

作　　者：梁兴 邵成浩 董晓强[2] 王珂琪 Liang Xing;Shao Chenghao;Dong Xiaoqiang;Wang Keqi(Department of Pancreatic-biliary Surgery,Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China;Department of General Surgery,First Affiliated Hospital of Soochow University,Suzhou 215006,China;Department of Gastroenterology,Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China)

机构地区：[1]海军军医大学第二附属医院胰胆外科,上海200003 [2]苏州大学附属第一医院普外科,苏州215006 [3]海军军医大学第二附属医院消化内科,上海200003

出　　处：《中华肝胆外科杂志》2024年第6期472-476,共5页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金(82303330、82200678)。

摘　　要：泛素化与去泛素化是常见的蛋白质翻译后的修饰方式。作为去泛素化酶中具有最多成员的泛素特异性蛋白酶(USPs)家族,其功能失调可导致一系列的生理损伤及病理改变,进而引起恶性肿瘤等疾病的发生发展。目前针对胰腺癌中去泛素化酶的功能机制研究相对较少,本文就USPs家族在胰腺癌发生发展中的研究进行综述,阐述其对胰腺癌恶性生物学行为的影响及作用机制,同时探讨USPs小分子抑制剂治疗胰腺癌的应用前景。Ubiquitination and deubiquitination are common post-translational modifications of proteins.As the largest family of deubiquitinating enzymes,ubiquitin-specific proteases(USPs)play critical roles in various physiological and pathological processes.Dysregulation of their functions results in a series of physiological damages and pathological alterations,ultimately contributing to the occurrence and progression of malignant tumors,including pancreatic cancer.Currently,research on the functional mechanisms of deubiquitinating enzymes in pancreatic cancer is still limited.This review focused on the research progress of USPs family in the occurrence and development of pancreatic cancer,to elucidate their impacts on the malignant biological behaviors of pancreatic cancer and its underlying mechanisms.The therapeutic potential of USPs inhibitors in pancreatic cancer were also discussed.

关 键 词：胰腺肿瘤 去泛素化 泛素特异性蛋白酶 泛素特异性蛋白酶抑制剂 

分 类 号：R735.9[医药卫生—肿瘤]