Oddi括约肌功能障碍动物模型的研究进展  

Advances in animal models of sphincter of Oddi dysfunction

作　　者：林豪男 梁易璇 赵王強 曹君葳 王天麒 梁卓睿 王长淼[1] Lin Haonan;Liang Yixuan;Zhao Wangqiang;Cao Junwei;Wang Tianqi;Liang Zhuorui;Wang Changmiao(Department of General SurgeryⅢ,First Affiliated Hospital of Dalian Medical University,Dalian 116000,China;School of Integrative Medicine,Dalian Medical University,Dalian 116000,China)

机构地区：[1]大连医科大学附属第一医院普外三科,大连116000 [2]大连医科大学中西医结合学院,大连116000

出　　处：《中华肝胆外科杂志》2024年第6期476-480,共5页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金(81774082)。

摘　　要：Oddi括约肌功能障碍(SOD)是指Oddi括约肌生理功能异常,可引发胆道、胰腺和肝脏等的一系列疾病。目前SOD的相关研究正成为热点,但是其发病机制并不明确,本文将综述国内外关于SOD的文献,分析不同实验动物模型的优劣势,并对药物和手术造模特点进行分析,为今后相关模型建立提供参考。Sphincter of Oddi dysfunction(SOD)refers to the abnormal physiological function of sphincter of Oddi,which causes a series of syndromes in biliary tract,pancreas and liver.At present,the related research of SOD is becoming a hot spot,but its pathogenesis is not clear.This article will review the domestic and international literatures on SOD,review the advantages and disadvantages of experimental animals such as rabbits,dogs and guinea pigs,and analyze the characteristics of drugs and surgical modeling,so as to provide references for future related model establishment.

关 键 词：奥狄括约肌功能障碍 动物 模型 综述 

分 类 号：R57[医药卫生—消化系统] R-332[医药卫生—内科学]