Malignant glaucoma treated by low-dose laser cycloplasty: a 1-year multicenter prospective noncomparative study  

作　　者：Hai-Shuang Lin Xiao-Ping Xu Xuan-Li Zheng Ji-Bing Wang Su-Jie Fan Zuo-HongWu Su-Mian Cheng Li-Jun Zhao Qin-Hua Cai Shao-Dan Zhang Shan-Shan Liu Ai-Guo Lyu Ying Zhang Hong Chen Dan-Ni Jiang Wu-Liang Li Nathan Congdon Clement C Tham Ming-Guang He Yuan-Bo Liang the Malignant Glaucoma TreatmentTrial Study(MGTT)Group 

机构地区：[1]Wenzhou Medical University,Wenzhou 325027,Zhejiang Province,China [2]Ningbo Eye Hospital,Ningbo 315100,Zhejiang Province,China [3]Weifang Eye Hospital,Weifang 261000,Shandong Province,China [4]Handan Eye Hospital,Handan 056000,Hebei Province,China [5]Aier Eye Hospital(Wuhan),Wuhan 430061,Hubei Province,China [6]Hebei Eye Hospital,Xingtai 054001,Hebei Province,China [7]The Third People’s Hospital of Dalian,Dalian 116033,Liaoning Province,China [8]First Affiliated Hospital of Suzhou University,Suzhou 215031,Jiangsu Province,China [9]National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,Wenzhou 325027,Zhejiang Province,China [10]Glaucoma Research Institute,Wenzhou Medical University,Wenzhou 325027,Zhejiang Province,China [11]Centre for Public Health,Queen’s University Belfast,Belfast BT71NN,UK [12]Orbis International,New York,USA [13]Department of Ophthalmology and Visual Sciences,the Chinese University of Hong Kong,Hong Kong SAR 999077,China [14]Centre for Eye Research Australia,University of Melbourne,Royal Victorian Eye and Ear Hospital,East Melbourne 3000,VIC,Australia [15]不详

出　　处：《International Journal of Ophthalmology(English edition)》2024年第7期1248-1254,共7页国际眼科杂志（英文版）

基　　金：Supported by the Program for Zhejiang Leading Talent of S&T Innovation(No.2021R52012);Development Projects of Zhejiang Province(No.2022C03112);Innovation Team Program of Wenzhou.

摘　　要：AIM:To report a one-year clinical outcomes of low-dose laser cycloplasty(LCP)among malignant glaucoma patients.METHODS:In this prospective,multicenter,noncomparative clinical study,participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in China.Patients were followed up at 1wk,1,3,6,and 12mo.Intraocular pressure(IOP),number of glaucoma medications,anterior chamber depth(ACD),and complications were recorded.Anatomical success was defined as the reformation of the anterior chamber based on slit-lamp biomicroscopy.Recurrence was defined by the presence of a shallow orflat anterior chamber after initial recovery from treatment.RESULTS:A total of 34 eyes received LCP.Mean IOP and medications decreased from 36.1±11.5 mm Hg with 3.3±1.5 glaucoma medications pre-treatment to 20.9±9.8 mm Hg(P<0.001)with 2.9±1.6 medications(P=0.046)at 1d,and 17.4±6.7 mm Hg(P<0.001)with 1.3±1.7 medications(P<0.001)at 12mo.The ACD increased from 1.1±0.8 mm at baseline to 1.7±1.0 mm and to 2.0±0.5 mm at 1d and 12mo,respectively.A total of 32(94.1%)eyes achieved initial anatomical success.During follow-up,2(5.9%)eyes failed and 8(23.5%)eyes relapsed,yielding a 12-month anatomical success rate of 64.3%.Complications including anterior synechia(8.82%),choroidal/ciliary detachment(5.88%)and hypopyon(2.94%)were observed within 1wk.CONCLUSION:LCP is simple,safe,and effective in reforming the anterior chamber in malignant glaucoma.

关 键 词：anterior chamber reformation intraocular pressure low-dose laser cycloplasty malignant glaucoma anatomical success 

分 类 号：R775[医药卫生—眼科]