Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis  

作　　者：Zi-Ling Hu Yu-Xuan Wang Zi-Yue Lin Wen-Shuo Ren Bo Liu Hui Zhao Qiong Qin 

机构地区：[1]Five Year Program of Ophthalmology and Optometry 2019,Beijing Tong Ren Hospital,Capital Medical University,Beijing 100054,China [2]Four Year Program of Traditional Chinese Pharmacy 2020,School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China [3]School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China [4]Beijing Key Laboratory of TCM Collateral Disease Theory Research,Beijing 100069,China [5]Five Year Program of Ophthalmology and Optometry 2021,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China [6]Biochemistry&Molecular Biology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第7期1344-1362,共19页国际眼科杂志（英文版）

基　　金：Supported by Capital Medical University Scientific Research Grant for Undergraduate Students(No.XSKY2023026).

摘　　要：Age-related macular degeneration(AMD)is a complicated disease that causes irreversible visual impairment.Increasing evidences pointed retinal pigment epithelia(RPE)cells as the decisive cell involved in the progress of AMD,and the function of anti-oxidant capacity of PRE plays a fundamental physiological role.Nuclear factor erythroid 2 related factor 2(Nrf2)is a significant transcription factor in the cellular anti-oxidant system as it regulates the expression of multiple anti-oxidative genes.Its functions of protecting RPE cells against oxidative stress(OS)and ensuing physiological changes,including inflammation,mitochondrial damage and autophagy dysregulation,have already been elucidated.Understanding the roles of upstream regulators of Nrf2 could provide further insight to the OS-mediated AMD pathogenesis.For the first time,this review summarized the reported upstream regulators of Nrf2 in AMD pathogenesis,including proteins and miRNAs,and their underlying molecular mechanisms,which may help to find potential targets via regulating the Nrf2 pathway in the future research and further discuss the existing Nrf2 regulators proved to be beneficial in preventing AMD.

关 键 词：NRF2 upstream regulators retinal pigment epithelia age-related macular degeneration oxidative stress 

分 类 号：R774.5[医药卫生—眼科]