急性脑梗死患者血清CTRP3及CTRP9水平与颈总动脉内膜中层厚度的相关性分析  

Correlation analysis of serum CTRP3,CTRP9 levels and common carotid artery intima-media thickness in patients with acute cerebral infarction

作　　者：刘宏娜 李晓宇 宋爱霞[1] 常青[1] 孙健[1] 薛茜[1] LIU Hong-na;LI Xiao-yu;SONG Ai-xia(Department of Neurology,The First Affiliated Hospital of Hebei North University,Zhangjiakou Hebei 075000,China;Department of Ultrasound,The First Affiliated Hospital of Hebei North University,Zhangjiakou Hebei 075000,China)

机构地区：[1]河北北方学院附属第一医院神经内科,河北张家口075000 [2]河北北方学院附属第一医院超声医学科,河北张家口075000

出　　处：《临床和实验医学杂志》2024年第11期1153-1156,共4页Journal of Clinical and Experimental Medicine

基　　金：河北省卫健委青年科技课题(编号:20190901);张家口市2021年市科技计划自筹经费项目(编号:2121099D)。

摘　　要：目的 探讨急性脑梗死患者血清C1q/肿瘤坏死因子相关蛋白(CTRP)3和CTRP9水平与颈总动脉内膜中层厚度(IMT)的相关性。方法 前瞻性纳入2020年12月至2023年5月河北北方学院附属第一医院收治的急性脑梗死患者87例作为观察组,另选取同期在该院体检的健康者85名作为对照组。采用酶联免疫吸附试验法检测两组研究对象血清中CTRP3、CTRP9水平,并通过彩色多普勒超声系统测量颈总动脉IMT。比较两组研究对象的血清CTRP3、CTRP9水平及颈总动脉IMT,比较两组研究对象的颈总动脉硬化程度,不同动脉硬化程度急性脑梗死患者血清CTRP3、CTRP9水平,分析血清CTRP3,CTRP9水平与急性脑梗死患者颈总动脉IMT的相关性。结果 观察组患者的血清CTRP3、CTRP9水平分别为(238.34±65.23)、(138.34±52.65)ng/mL,均明显低于对照组[(372.14±83.47)、(249.25±78.32)ng/mL],颈总动脉IMT为(1.34±0.41) mm,显著高于对照组[(0.74±0.12)mm],差异均有统计学意义(P<0.05)。观察组患者的颈总动脉硬化程度正常占比为9.20%,明显低于对照组(72.94%),内膜增厚和斑块形成占比分别为31.03%、57.47%,均明显高于对照组(17.64%、9.41%),差异均有统计学意义(P<0.05)。随着颈总动脉IMT的增加,血清CTRP3和CTRP9的水平显著降低,差异均有统计学意义(P<0.05)。血清CTRP3和CTRP9水平与颈总动脉IMT均呈负相关(r=-0.461、-0.592,P<0.05),而CTRP3和CTRP9之间呈正相关(r=0.498,P<0.05)。结论 急性脑梗死患者血清CTRP3和CTRP9水平与颈总动脉IMT有明显负相关性。CTRP3和CTRP9可能作为动脉粥样硬化和急性脑梗死的潜在生物标志物,为临床预测和干预缺血性脑卒中提供重要信息。Objective To investigate the correlation between serum levels of human C1q/tumor necrosis factor-associated protein(CTRP)3 and CTRP9 and common carotid artery intima-media thickness(IMT)in patients with acute cerebral infarction.Methods A total of 87 patients with acute cerebral infarction admitted to the First Affiliated Hospital of Hebei North University from December 2020 to May 2023 were prospectively included as the observation group,and 85 healthy people who underwent physical examination in the hospital during the same period were selected as the control group.The levels of CTRP3 and CTRP9 in serum of the two groups were detected by enzyme-linked immunosorbent assay,and the common carotid artery IMT was measured by color Doppler ultrasound.The serum CTRP3 and CTRP9 levels and common carotid artery IMT of the two groups were compared,the degree of common carotid artery sclerosis of the two groups,and the serum CTRP3 and CTRP9 levels of acute cerebral infarction patients with different degrees of arteriosclerosis were analyzed,and the correlation between serum CTRP3 and CTRP9 levels and common carotid artery IMT of acute cerebral infarction patients was analyzed.Results The levels of serum CTRP3 and CTRP9 in the observation group of patients were(238.34±65.23)and(138.34±52.65)ng/mL,respectively,which were significantly lower than those in the control group[(372.14±83.47)and(249.25±78.32)ng/mL],the common carotid artery IMT was(1.34±0.41)mm,which was significantly higher than that in the control group[(0.74±0.12)mm],and the differences were statistically significant(P<0.05).The normal proportion of carotid artery atherosclerosis in the observation group was 9.20%,which was significantly lower than that in the control group(72.94%),the proportion of intimal thickening and plaque formation in the observation group were 31.03%and 57.47%,respectively,which were significantly higher than those in the control group(17.64%and 9.41%),and the differences were statistically significant(P<0.05).With the increase o

关 键 词：脑梗死 颈总动脉 CTRP3 CTRP9 内膜中层厚度 相关性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]