MSCT特征及血清Gal-3、TSH、E-cad与PTMC颈部淋巴结转移的相关分析  

Correlation between characteristics of MSCT,the serum Gal-3,TSH,E-cad and neck lymph node metastasis in PTMC

作　　者：周逢春 陈传新 童朝阳 ZHOU Feng-chun;CHEN Chuan-xin;TONG Chao-yang(Department of Imaging,Ma'anshan Seventeenth Metallurgical Hospital,Ma'anshan Anhui 241000,China)

机构地区：[1]马鞍山十七冶医院影像科,安徽马鞍山241000

出　　处：《临床和实验医学杂志》2024年第11期1207-1211,共5页Journal of Clinical and Experimental Medicine

基　　金：安徽高校自然科学研究项目(编号:KJ2021A0912)。

摘　　要：目的 分析多层螺旋CT(MSCT)特征及血清半乳糖凝集素-3(Gal-3)、促甲状腺激素(TSH)、上皮钙黏素(E-cad)与甲状腺微小乳头状癌(PTMC)颈部淋巴结转移(LNM)的相关性。方法 回顾性选择2018年1月至2019年12月于马鞍山十七冶医院就诊的PTMC患者84例纳入实验组,选择同期于本院治疗的甲状腺良性结节患者84例纳入对照组。观察两组病灶及淋巴结的MSCT特征(病灶多发、最大直径、形态不规则、微钙化、结节突破甲状腺包膜、淋巴结肿大、淋巴结不均匀强化),并检查与比较两组血清Gal-3、TSH、E-cad水平。统计实验组颈部LNM、无颈部LNM患者例数,并观察实验组颈部LNM、无颈部LNM患者病灶及淋巴结的MSCT特征,血清Gal-3、TSH、E-cad水平。分析PTMC患者病灶的MSCT特征及血清Gal-3、TSH、E-cad水平与颈部LNM的相关性。结果 实验组病灶多发比例、最大直径≥5 mm比例、形态不规则比例、结节突破甲状腺包膜比例、淋巴结肿大比例及淋巴结不均匀强化比例分别为63.10%、67.86%、72.62%、54.76%、73.81%、51.19%,均大于对照组(32.14%、38.10%、4.76%、0、17.86%、0),差异均有统计学意义(P<0.05);两组微钙化比例比较,差异无统计学意义(P>0.05)。实验组Gal-3、TSH、E-cad水平分别为(4.73±0.49)μg/L、(2.40±0.26) mIU/L、(109.64±13.47) ng/mL,均高于对照组[(1.69±0.18)μg/L、(1.28±0.13) mIU/L、(57.63±5.89) ng/mL],差异均有统计学意义(P<0.05)。颈部LNM、无颈部LNM患者例数分别为19例、65例。颈部LNM患者病灶多发、最大直径≥5 mm、形态不规则、结节突破甲状腺包膜、淋巴结肿大及淋巴结不均匀强化等比例均大于无颈部LNM患者,差异均有统计学意义(P<0.05);颈部LNM、无颈部LNM患者微钙化比例比较,差异无统计学意义(P>0.05)。颈部LNM患者血清Gal-3、TSH、E-cad水平均高于无颈部LNM患者,差异均有统计学意义(P<0.05)。经Pearson相关分析,病灶多发、最大直径�Objective To analyze the correlation between characteristics of multi-slice spiral CT(MSCT),serum Galectin-3(Gal-3),thyroid stimulating hormone(TSH),E-cadherin(E-cad)and neck lymph node metastasis(LNM)in papillary thyroid micro-carcinoma(PTMC).Methods A total of 84 PTMC patients treated in Ma'anshan Seventeenth Metallurgical Hospital from January 2018 to December 2019 were included in the experimental group,and 84 patients with benign thyroid nodules treated in our hospital during the same period were included in the control group.The MSCT characteristics(multiple lesions,maximum diameter,irregular shape,microcalcifications,nodules breaking through the thyroid capsule,lymph node enlargement,uneven enhancement of lymph nodes)of the two groups were observed,the levels of serum Gal-3,TSH and E-cad in the two groups were observed and compared.The number of patients with neck LNM and without neck LNM in the experimental group was counted,and the MSCT characteristics,serum Gal-3,TSH and E-cad levels of neck LNM and non-neck LNM patients in the experimental group were observed.The correlation between the MSCT characteristics and serum Gal-3,TSH,E-cad levels and neck LNM in patients with PTMC was analyzed.Results The proportion of multiple lesions,the proportion of maximum diameter≥5 mm,the proportion of irregular shape,the proportion of nodules breaking through the thyroid capsule,the proportion of lymph node enlargement and the proportion of uneven enhancement of lymph node in the experimental group were 63.10%,67.86%,72.62%,54.76%,73.81%,51.19%,respectively,which were higher than those in the control group(32.14%,38.10%,4.76%,0,17.86%,0),the differences were statistically significant(P<0.05).There was no statistically significant difference in microcalcification ratio between the two groups(P>0.05).The levels of Gal-3,TSH and E-cad in the experimental group were(4.73±0.49)μg/L,(2.40±0.26)mIU/L,(109.64±13.47)ng/mL,respectively,which were higher than those in the control group[(1.69±0.18)μg/L,(1.28±0.13)mIU/L,(

关 键 词：多层螺旋CT 半乳糖凝集素-3 促甲状腺激素 上皮钙黏素 甲状腺微小乳头状癌 颈部淋巴结转移 

分 类 号：R736.1[医药卫生—肿瘤]