基于氧化应激的运动抗抑郁症作用研究进展  

Research progress on the anti-depression effect of exercise based on oxidative stress

作　　者：张谐 王志杰 王宁[1] ZHANG Xie;WANG Zhijie;WANG Ning(Medical College,Xijing University,Shaanxi,Xi’an 710123,China;The Second Affiliated Hospital of Air Force Medical University,Shaanxi,Xi’an 710038,China)

机构地区：[1]西京学院医学院,陕西西安710123 [2]空军军医大学第二附属医院,陕西西安710038

出　　处：《中国医药科学》2024年第12期35-38,共4页China Medicine And Pharmacy

基　　金：空军军医大学第二附属医院社会人才基金资助计划项目(2021SHRC041);西京学院校科研基金项目(XJ210105)。

摘　　要：抑郁症是一种严重的慢性反复发作的精神类疾病,是先天因素与后天因素共同作用的结果,且在青少年中抑郁症的患病率逐年上升。部分抑郁症患者甚至出现自杀倾向,严重影响了患者的生理、心理及社会功能。其发病机制尚未完全明确,但有研究证实抑郁症的发生发展与机体抗氧化防御系统失衡有关。通过体育运动调控氧化应激相关信号通路可提高神经系统抗氧化功能,进而达到抗抑郁目的。本文在综述抑郁症氧化应激反应相关机制的基础上,总结了不同运动疗法在抑郁症中的治疗作用,以期为日后临床中抑郁症的预防与治疗提供理论参考。Depression is a serious chronic recurrent mental illness that is the result of a combination of congenital and acquired factors,and the incidence of depression in adolescents is increasing year by year.Some patients with depression even exhibit suicidal tendencies,seriously affecting their physiological,psychological,and social functions.The pathogenesis of depression is not yet fully understood,but studies have shown that the occurrence and development of depression are related to the imbalance of the body’s antioxidant defense system.By regulating oxidative stress-related signaling pathways through sports,the antioxidant function of the nervous system can be improved,thereby achieving the goal of antidepressants.Based on summarizing the relevant mechanisms of oxidative stress response in depression,this article summarizes the therapeutic effects of different exercise therapies in depression,to provide theoretical refere nce for the prevention and treatment of depression in future clinical practice.

关 键 词：抑郁症 氧化应激 信号通路 运动 

分 类 号：R749.4[医药卫生—神经病学与精神病学]