注射用鼠神经生长因子联合康复训练治疗脑性瘫痪患儿的临床疗效分析  

Clinical efficacy analysis of mouse nerve growth factor for injection combined with rehabilitation training in the treatment of children with cerebral palsy

作　　者：张艳梅 ZHANG Yan-mei(Women and Children's Branch Hospital,Chengwu County People's Hospital,Heze 274200,China)

机构地区：[1]成武县人民医院妇儿院区,274200

出　　处：《中国现代药物应用》2024年第13期10-13,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究注射用鼠神经生长因子与康复训练联合应用治疗脑性瘫痪的疗效。方法选取300例脑性瘫痪患儿,经信封法分为对照组(150例,康复训练)、观察组(150例,注射用鼠神经生长因子+康复训练)。对比两组粗大运动功能、精细运动功能、语言功能、治疗效果。结果治疗3个月后,两组卧位、坐位、爬跪、站立、走跑跳评分均较治疗前升高,且观察组卧位、坐位、爬跪、站立、走跑跳评分分别为(40.23±5.46)、(50.63±4.78)、(34.23±3.98)、(31.25±4.35)、(58.64±5.78)分,较对照组的(32.18±5.35)、(41.27±4.62)、(29.01±3.86)、(26.54±4.21)、(51.05±5.63)分高(P<0.05)。治疗3个月后,两组上肢关节活动、视觉追踪、手眼协调能力、抓握能力、操作能力评分均较治疗前升高,且观察组上肢关节活动、视觉追踪、手眼协调能力、抓握能力、操作能力评分分别为(28.76±2.45)、(19.92±1.67)、(45.76±2.99)、(30.25±2.54)、(33.54±2.56)分,较对照组的(25.43±2.40)、(16.87±1.62)、(39.02±2.84)、(27.11±2.43)、(28.46±2.45)分高(P<0.05)。治疗3个月后,两组语言理解、语言表达评分均较治疗前升高,且观察组语言理解评分(64.76±3.45)分、语言表达评分(62.89±3.25)分较对照组的(59.62±3.37)、(57.04±3.17)分高(P<0.05)。观察组治疗总有效率95.33%高于对照组的76.67%(P<0.05)。结论脑性瘫痪患儿联用注射用鼠神经生长因子、康复训练,可提高粗大运动功能、精细运动功能、治疗效果,值得临床推广。Objective To explore the efficacy of mouse nerve growth factor for injection combined with rehabilitation training in the treatment of children with cerebral palsy.Methods 300 children with cerebral palsy were selected and divided into a control group(150 cases,rehabilitation training)and an observation group(150 cases,mouse nerve growth factor for injection+rehabilitation training)by envelope method.The gross motor function,fine motor function language function,and treatment effect were compared between the two groups.Results After 3 months of treatment,the scores of lying,sitting,crawling and kneeling,standing,walking,running and jumping in both groups were higher than those before treatment;the scores of lying,sitting,crawling and kneeling,standing,walking and running and jumping were(40.23±5.46),(50.63±4.78),(34.23±3.98),(31.25±4.35)and(58.64±5.78)points,which were higher than(32.18±5.35),(41.27±4.62),(29.01±3.86),(26.54±4.21)and(51.05±5.63)points in the control group(P<0.05).After 3 months of treatment,the scores of upper limb joint movement,visual tracking,hand-eye coordination,grasping ability,and manipulation ability in both groups were higher than those before treatment;the scores of upper limb joint movement,visual tracking,hand-eye coordination,grasping ability and maneuvering ability in the observation group were(28.76±2.45),(19.92±1.67),(45.76±2.99),(30.25±2.54)and(33.54±2.56)points,which were higher than(25.43±2.40),(16.87±1.62),(39.02±2.84),(27.11±2.43)and(28.46±2.45)points in the control group(P<0.05).After 3 months of treatment,the language comprehension and language expression scores in both groups were higher than those before treatment;the language comprehension score in the observation group was(64.76±3.45)points and the language expression score was(62.89±3.25)points,which were higher than(59.62±3.37)and(57.04±3.17)points in the control group(P<0.05).The total effective rate of treatment in the observation group was 95.33%,which was higher than 76.67% in the control g

关 键 词：脑性瘫痪 脑血流动力学 注射用鼠神经生长因子 治疗效果 康复训练 精细运动功能 粗大运动功能 

分 类 号：R742.3[医药卫生—神经病学与精神病学]