TCT联合HPV检测应用于妇女早期宫颈癌筛查作用分析  

Analysis of the role of TCT combined with HPV detection in screening early cervical cancer in women

作　　者：刘繁杰 Liu Fanjie(Department of Obstetrics and Gynecology,Dehui Maternal and Child Health and Family Planning Service Center,Changchun 130300,China)

机构地区：[1]德惠市妇幼保健计划生育服务中心妇产科,吉林长春130300

出　　处：《实用妇科内分泌电子杂志》2024年第15期119-121,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的分析TCT联合HPV检测应用于35~65岁妇女早期宫颈癌筛查作用。方法选取本院筛查早期宫颈癌的5000例妇女为研究对象,所有检查妇女均接受液基薄层细胞检测(TCT)与HPV(高危型人乳头状瘤病毒DNA检查),将活检病理学结果作为“金标准”,统计不同检测方式的筛查效果。结果TCT联合HPV检测在早期宫颈癌中检出率显著高于两项方法单独应用检出率,差异有统计学意义(P<0.05)。TCT在SCC、HSIL以及LSIL等方面阳性检出率明显低于正常以及炎症女性HPV阳性检出率,差异有统计学意义(P<0.05)。与“金标准”检查结果相比,TCT联合HPV检测在CINⅢ级以上病变检出率非常高,筛查作用明显,差异有统计学意义(P<0.05)。结论在育龄妇女早期宫颈癌筛查过程中应用TCT联合HPV检测对病变组织检出率敏感性较高,可有效提高筛查检出率,减少漏诊及误诊情况。Objective To analyze the role of TCT combined with HPV detection in early cervical cancer screening in women aged 35-65.Methods A total of 5000 women screened for early cervical cancer in our hospital were selected as the research subjects.All examined women underwent liquid based thin-layer cell testing(TCT)and HPV(high-risk human papillomavirus DNA test),and the biopsy pathological results were used as the"gold standard"to calculate the screening effects of different testing methods.Results The detection rate of TCT combined with HPV detection in early cervical cancer was significantly higher than that of the two methods used alone,and the difference was statistically significant(P<0.05).The positive detection rate of TCT in SCC,HSIL,and LSIL was significantly lower than that in normal and inflamed women with HPV,and the difference was statistically significant(P<0.05).Compared with the"gold standard"test results,the detection rate of CIN grade II and above lesions in TCT combined with HPV testing is very high,and the screening effect is significant,with statistical significance(P<0.05).Conclusion The application of TCT combined with HPV detection in the screening process of early cervical cancer in women of childbearing age is highly sensitive to the detection rate of diseased tissues,which can effectively improve the screening detection rate and reduce missed diagnosis and misdiagnosis.

关 键 词：液基细胞学检查 高危型人乳头状瘤病毒DNA检查 早期宫颈癌 35~65岁妇女 筛查效果 

分 类 号：R737.33[医药卫生—肿瘤]