维生素C联合碳酸氢钠中和卢戈氏碘的安全性和有效性  

Safety and efficacy of vitamin C combined with sodium bicarbonate to neutralize Lugol's iodine

作　　者：孙红 吴传楠[3] 陈光侠 刘世育 张国新 Hong;WU Chuannan;CHEN Guangxia;LIU Shiyu;ZHANG Guoxin(First Clinical Medical College,Xuzhou Medical University,Xuzhou 221004,CHINA)

机构地区：[1]徐州医科大学第一临床医学院,江苏221004 [2]睢宁县人民医院消化内科,江苏221004 [3]徐州医科大学附属徐州市立医院消化内科,江苏221004 [4]南京医科大学第一附属医院消化内科,江苏221004

出　　处：《江苏医药》2024年第6期541-546,F0003,共7页Jiangsu Medical Journal

基　　金：徐州市科技项目(KC22095);徐州市医学领军人才培养项目(XWRCHT20210025)。

摘　　要：目的探讨维生素C联合碳酸氢钠中和卢戈氏碘的安全性和有效性。方法行普通胃镜检查的受试者156例,随机分为三组,每组52例。常规内镜检查后,对食管喷洒2%卢戈氏碘液10mL。碘染结束后,硫代硫酸钠(STS)组喷洒5%STS溶液20mL,维生素C组喷洒2%维生素C溶液20mL,维生素C+碳酸氢钠组喷洒2%维生素C及1%碳酸氢钠混合液20mL。分别于碘染后5min、30min、24h统计不适症状发生情况,评估食管黏膜及胃黏液池的褪色效果。结果维生素C+碳酸氢钠组碘染后24h内不良反应总发生率低于STS组(P<0.05)。碘染后5min,维生素C+碳酸氢钠组不适症状评分低于STS组(P<0.05)。三组食管黏膜、胃黏液池褪色效果评分比较差异均无统计学意义(P>0.05)。结论维生素C联合碳酸氢钠可用于中和卢戈氏碘,不良反应发生率低,且不影响褪色效果。Objective To observe the safety and efficacy of vitamin C combined with sodium bicarbonate for neutralizing Lugol's iodine.Methods A total of 156 patients undergoing general gastroscopy were divided into three groups with 52 cases each.After routine endoscopy,2%Lugol's iodine solution 10 mL was sprayed into the esophagus for iodine staining.After iodine staining,group A was sprayed with 5%sodium thiosulfate solution 20 mL,group B was sprayed with 2%vitamin C solution 20 mL and group C was sprayed with 2%vitamin C and 1%sodium bicarbonate mixture 20 mL.The incidences of discomfort symptoms were evaluated at 5 minutes,30 minutes and 24 hours after iodine staining.The fading effects of esophageal mucosa and gastric mucous pool were evaluated.Results The incidence of total adverse reactions within 24 hours after iodine staining was lower in group C than that in group A(P<0.05).The discomfort symptom score of group C was lower than that of group A at 5 minutes after iodine staining(P<0.05).There were no significant differences in the fading effect scores of esophageal mucosa and gastric mucous pool among the three groups(P>0.05).Conclusion Vitamin C combined with sodium bicarbonate can be used to neutralize Lugol's iodine with low incidence of adverse reactions and without influence on the fading effect.

关 键 词：卢戈氏碘 维生素C 碳酸氢钠 

分 类 号：R735[医药卫生—肿瘤]