TL1A作为炎症性肠病治疗靶点的研究进展  

Progress in research of TNF-like cytokine 1A as a therapeutic target for inflammatory bowel disease

作　　者：战蓉蓉 王冬[1] 张晓岚[1] Rong-Rong Zhan;Dong Wang;Xiao-Lan Zhang(Depart-ment of Gastroenterology,The Second Hospital of Hebei Medical University,Hebei Key Laboratory of Gastroenterology,Hebei Institute of Gastroenterology,Shijiazhuang 050000,Hebei Province,China)

机构地区：[1]河北医科大学第二医院消化内科,河北省消化病学研究所消化内科重点实验室,河北省石家庄市050000

出　　处：《世界华人消化杂志》2024年第6期397-404,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金,No.81370501和No.81870381.

摘　　要：肿瘤坏死因子超家族成员(TNF superfamily member,TNFSF)和肿瘤坏死因子受体超家族蛋白由多种分子组成,对免疫系统的发育和功能起着关键作用.TNFSF15基因编码的肿瘤坏死因子样配体1(tumor necrosis factor-like ligand 1 aberrance,TL1A)是一种Ⅱ型跨膜蛋白,有可溶性或膜结合两种存在形式,通过结合其功能性受体-死亡受体3[(death receptor 3,DR3)或TNFFRSFf25]为下游信号通路提供刺激信号,调节效应细胞的增殖、激活、凋亡以及细胞因子、趋化因子的产生.TL1A/DR3细胞因子系统已成为黏膜免疫的重要模块,参与维持肠道稳态,促进慢性炎症反应的发生和发展,因此,在炎症性肠病的发生发展过程中也发挥重要作用.TNF and TNF receptor superfamily proteins(TNFSF and TNFRSF)are composed of a variety of molecules that play a key role in the development and function of the immune system.TNF-like cytokine 1A(TL1A),encoded by the TNFSF15 gene,is a typeⅡtransmembrane protein that exists in both soluble and membrane-bound forms.By binding to its functional receptor-death receptor 3(DR3 or TNFFRSFf25),TL1A provides stimulation signals to downstream signaling pathways,and then regulates the proliferation,activation,apoptosis,and production of cytokines and chemokines in effector cells.The TL1A/DR3 cytokine system has become an important module of mucosal mucosal immunity,which is involved in maintaining intestinal homeostasis and promoting the occurrence and development of chronic inflammatory response,so it also plays an important role in the occurrence and development of inflammatory bowel disease.

关 键 词：TL1A 炎症性肠病 肠纤维化 治疗靶点 专家述评 

分 类 号：R574[医药卫生—消化系统]