数字化技术辅助放射性粒子精准治疗腭部腺样囊性癌的近期疗效分析  

Short-term efficacy of brachytherapy combined with digital technology for the treatment of palatal adenoid cystic carcinoma

作　　者：陈霖 葛良玉 孟箭 CHEN Lin;GE Liang-yu;MENG Jian(Department of Stomatology,Xuzhou Central Hospital,Xuzhou 221000,China)

机构地区：[1]徐州医科大学徐州临床学院,徐州市中心医院口腔科,徐州医科大学口腔医学院,徐州221000

出　　处：《北京口腔医学》2024年第3期196-199,共4页Beijing Journal of Stomatology

基　　金：徐州市科技计划项目(KC21187)。

摘　　要：目的探讨在125I粒子近距离放射治疗腭部腺样囊性癌中辅助应用数字化技术的有效性及技术特点。方法回顾我院应用125I放射性粒子联合数字化技术精准治疗的腭部腺样囊性癌患者11例,通过随访记录患者癌症的局部控制情况及相关并发症的发生,总结其近期疗效及技术特点。结果所有患者均在3D打印个性化手术模板引导下植入125I放射性粒子进行治疗。术后复查CT显示,植入粒子分布均匀,均与术前目标一致。术后1个月总有效率为81.8%,局部控制率为100%。术后6个月总有效率为100%,仅有2例术后出现明显口干症状。结论数字化技术辅助放射性粒子植入治疗腭部腺样囊性癌获得了较好的近期疗效和局部控制率,为无法手术的腭部腺样囊性癌患者提供了可行的、微创的精准治疗方案。Objective To evaluate the effectiveness of 125I seed brachytherapy assisted by digital technology for the treatment of adenoid cystic carcinoma of palate.Methods Eleven patients with palatal adenoid cystic carcinoma treated with 125I seed brachytherapy combined with digital technology were reviewed.The local control of the cancer and the related complications were recorded to summarize the short-term efficacy and technical characteristics.Results 125I seeds were implanted in the patients under the guidance of 3d-printed personalized surgical template.Postoperative CT scan showed that the implanted particles were evenly distributed and consistent with the preoperative objectives.The total effective rate was 81.8%and the local control rate was 100%one month after treatment.The total effective rate was 100%six months after treatment.Conclusions Theoretically,the treatment for adenoid cystic carcinoma of the palate with 125I seed implantation assisted by digital technology could achieve the local maximum dose precisely.It could also obtain good short-term curative effect and local control rate.This study provides a feasible,minimally invasive and precise treatment for patients with unresectable adenoid cystic carcinoma of the palate.Digital technology assisted brachytherapy could achieve good short-term efficacy and local control rate in the treatment of palatal adenoid cystic carcinoma,providing a feasible and minimally invasive precise treatment approach for patients with inoperable palatal adenoid cystic carcinoma.

关 键 词：腺样囊性癌 近距离放疗 数字化技术 

分 类 号：R739.8[医药卫生—肿瘤]