鼻腔鼻窦颅底孤立性纤维性肿瘤12例临床分析  

Clinical analysis of 12 cases of solitary fibrous tumors in nasal cavity, sinuses and skull base

作　　者：齐治宇 于龙刚[1] 颜旭东[1] 王琳[1] 张雪琰 李顺科 吴策 姜彦[1] QI Zhiyu;YU Longgang;YAN Xudong;WANG Lin;ZHANG Xueyan;LI Shunke;WU Ce;JIANG Yan(Department of Otolaryngology Head and Neck Surgery and the Department of Skull Base Surgery,Affiliated Hospital of Qingdao University,Qingdao,266000,China)

机构地区：[1]青岛大学附属医院耳鼻咽喉头颈外科/鼻颅底外科,山东青岛266000

出　　处：《临床耳鼻咽喉头颈外科杂志》2024年第6期518-523,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：山东省自然科学基金(No:ZR2023MH027)。

摘　　要：目的总结分析鼻腔鼻窦颅底孤立性纤维性肿瘤(solitary fibrous tumor,SFT)的临床表现、诊疗方法及预后特点。方法回顾性分析青岛大学附属医院耳鼻咽喉头颈外科和颅底外科2014年4月-2022年1月收治的12例鼻腔鼻窦颅底SFT患者的临床资料,其中耳鼻咽喉头颈外科收治患者4例、颅底外科收治患者8例,分析其临床特点、诊疗经过及预后情况。患者均行手术治疗,其中4例术后辅助放化疗,8例未行放化疗。结果术后随访12~60个月,4例术后辅助放化疗的患者均预后良好;8例未行放化疗患者中6例预后良好,另2例复发;4例患者既往有SFT手术史,复发后收治于青岛大学附属医院治疗,其中1例术后复发。所有患者均无转移。结论鼻腔鼻窦颅底SFT较为罕见,对于该病最有效的治疗手段为手术切除,术后辅助放化疗及术后长期随访可以实现较好的预后。综合治疗中完整性手术切除肿瘤是治疗的关键。Objective To summarize and analyze the clinical manifestations,diagnosis and management and prognostic features of solitary fibrous tumor(SFT)in nasal cavity,sinus and skull base.Methods The clinical data of 12 patients with STF from nasal cavity,sinus and cranial base admitted to the Affiliated Hospital of Qingdao University from April 2014 to January 2022 were retrospectively analyzed,including 4 patients admitted to the department of Otolaryngology head and neck surgery and 8 patients admitted to the department of skull base surgery The clinical characteristics,diagnosis,management and prognosis were analyzed.Results Twelve patients were included in this research,including 7 males and 5 females.All patients received surgical treatment,and 4 patients also received postoperative adjuvant chemoradiotherapy.After follow-up for 12-60 months,4 patients with adjuvant radiotherapy and chemotherapy had a good prognosis,and among 8 patients who did not receive radiotherapy and chemotherapy,6 patients had good prognosis and 2 patients showed relapse.Four patients with a history of recurrence of SFT after surgery were admitted to our hospital for surgical treatment,in which 1 patient had relapse after surgery,and none had metastasis.Nasal cavity and sinus to skull base SFT is rare.The most effective treatment for this disease is surgical resection,and postoperative adjuvant chemoradiation and long-term follow-up can achieve a better prognosis.En bloc resection is the key to treatment success.

关 键 词：鼻腔鼻窦肿瘤 颅底肿瘤 孤立性纤维性肿瘤 

分 类 号：R739.62[医药卫生—肿瘤]