甘草酸二铵注射液与水飞蓟宾胶囊治疗慢性乙型肝炎对患者肝纤维化的影响  

Effects of Diammonium Glycyrrhizinate Injection and Silybin Capsule on Hepatic Fibrosis in Patients with Chronic Hepatitis B

作　　者：吴杰[1] 杜彩萍 翟祥宇 WU Jie;DU Cai-Ping;ZHAI Xiang-Yu(Department of Pharmaceutical Technology,Xuzhou Higher Vocational School of Medicine,Xuzhou 221116,China;School of Basic Medicine,Xuzhou Medical University,Xuzhou 221004,China;Medical Department of Jiangsu Xuzhou Huaihai International Port Area People's Hospital,Xuzhou 221318,China)

机构地区：[1]江苏省徐州医药高等职业学校药学技术系,江苏徐州221116 [2]江苏徐州医科大学基础医学院,江苏徐州221004 [3]江苏徐州淮海国际港务区人民医院医务科,江苏徐州221318

出　　处：《中国药物经济学》2024年第5期51-55,共5页China Journal of Pharmaceutical Economics

摘　　要：目的 探讨甘草酸二铵注射液、水飞蓟宾胶囊治疗慢性乙型肝炎对患者肝纤维化的影响。方法 选取2021年1月至2022年6月港务区人民医院收治的慢性乙型肝炎患者96例为研究对象,按随机数字表法分为对照组与观察组,各48例。对照组给予甘草酸二铵注射液治疗,观察组采用水飞蓟宾胶囊治疗。比较两组患者临床疗效、肝功能指标、肝纤维化指标、炎症反应及氧化应激反应指标、肝功能损伤程度、生命质量及不良反应。结果 观察组治疗有效率明显高于对照组(P<0.05)。治疗后观察组胆红素(TBil)水平、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、碱性磷酸酶(ALP)、透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(PC-Ⅲ)、Ⅳ型胶原(C-Ⅳ)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、丙二醛(MDA)明显低于对照组(P<0.05),超氧化物歧化酶(SOD)、EORTC生命质量测定量表(QLQ-C30)评分明显高于对照组,差异有统计学意义(P<0.05)。治疗后观察组无肝损伤、轻度肝损伤患者比例明显高于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论 甘草酸二铵注射液、水飞蓟宾胶囊治疗慢性乙型肝炎均有一定临床效果,但水飞蓟宾胶囊对患者肝功能、肝纤维化及生命质量的改善作用明显优于甘草酸二铵注射液。Objective To explore the effects of Diammonium Glycyrrhizinate injection and Silybin capsule on hepatic fibrosis in patients with chronic hepatitis B.Methods A total of 96 patients with chronic hepatitis B admitted to the People's Hospital of Port District from January 2021 to June 2022 were selected as the study objects,and were divided into control group and observation group according to random number table method,with 48 cases in each group.The control group was treated with diammonium glycyrrhizinate injection,and the observation group was treated with silybin capsule.The clinical efficacy,liver function indexes,liver fibrosis indexes,inflammation and oxidative stress indexes,liver function injury degree,quality of life and adverse reactions were compared between the two groups.Results The effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the levels of bilirubin(TBil),alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),hyaluronic acid(HA),laminin(LN),type Ⅲ procollagen(PC-Ⅲ),type Ⅳcollagen(C-Ⅳ),interleukin-4(IL-4),interleukin-10(IL-10)) and malondialdehyde(MDA) in the observation group were significantly lower than those in control group,and the scores of superoxide dismutase(SOD) and EORTC Quality of Life Scale(QLQ-C30) were significantly higher than those in control group,with statistical significance(P<0.05).After treatment,the proportion of patients with no liver injury and mild liver injury in observation group was significantly higher than that in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Diammonium Glycyrrhizinate injection and Silybin capsule have certain clinical effects in the treatment of chronic hepatitis B,but Silybin capsule is significantly better than Diammonium Glycyrrhizinate injection in improving liver function,liver fibrosis and quality of life.

关 键 词：慢性乙型肝炎 甘草酸二铵注射液 水飞蓟宾胶囊 肝纤维化 

分 类 号：R575.1[医药卫生—消化系统] R975[医药卫生—内科学]