具有杀菌和除草活性的异噁唑类化合物研究进展  

Research progress of isoxazole compounds with fungicidal and herbicidal activities

作　　者：廖昌洲 胡日查 李俊凯[1,2] 曾志刚 LIAO Changzhou;HU Richa;LI Junkai;ZENG Zhigang(Yangtze University,Engineering Research Center of Ecology and Agricultural Use of Wetland,Ministry of Education,Hubei Key Laboratory of Waterlogging Disaster and Agricultural Use of Wetland,College of Agriculture,Jingzhou 434025,Hubei,China;Yangtze University,Institute of Pesticides,Jingzhou 434025,Hubei,China;School of Nuclear Technology and Chemistry&Biology,Hubei University of Science and Technology,Xianning 437100,Hubei,China)

机构地区：[1]长江大学农学院湿地生态与农业利用教育部工程研究中心,涝害与湿地农业利用湖北省重点实验室,湖北荆州434025 [2]长江大学农学院农药研究所,湖北荆州434025 [3]湖北科技学院核技术与化学生物学院,湖北咸宁437100

出　　处：《农药》2024年第7期469-482,共14页Agrochemicals

基　　金：湖北省自然科学基金项目(2022CFB008);国家自然科学基金项目(31601675、32260685);长江大学湿地生态与农业利用教育部工程研究中心开放基金项目(KF202106)资助。

摘　　要：含氮杂环广泛存在于天然产物和药物分子中,在药物开发领域扮演着重要角色。异噁唑作为含氮杂环中重要一员,具有广阔的应用前景。异噁唑及其衍生物是重要的有机合成子,具有良好的杀菌、除草、杀虫等生物活性。对2017年以来报道的具有杀菌和除草活性的异噁唑类化合物及其合成路线进行了综述,并概括了各类化合物对不同病原菌、杂草的防治效果,简要分析了不同结构与生物活性之间的关系,以期为异噁唑类农药的研究开发提供参考。Nitrogen-containing heterocycles,pivotal in drug development,are prevalent in both natural products and pharmaceutical compounds.Among these,isoxazole stands out as a promising candidate.Isoxazole and its derivatives serve as important organic synthons,boasting enhanced fungicidal,herbicidal,insecticidal,and other bioactive properties.This review focuses on isoxazoles exhibiting fungicidal and herbicidal activities,along with their synthesis routes reported since 2017.We comprehensively outlined the efficacy of analogues against various pathogens and weeds and briefly examines the correlation between structural variations and biological activities.This review offers insights into the advancement of isoxazole-based pesticides.

关 键 词：异噁唑 杀菌 除草 生物活性 

分 类 号：S482[农业科学—农药学] TQ455[农业科学—植物保护] TQ457[化学工程—农药化工]