神经内分泌肿瘤肝转移的外科干预策略  

Surgical intervention strategies for liver metastasis of neuroendocrine tumors

作　　者：王俊青[1] 陈拥军[1] WANG Junqing;CHEN Yongjun(Department of General Surgery,Department of Hepatobiliary Surgery,Shanghai Institute of Digestive Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院普外科,肝胆外科,上海消化外科研究所,上海200025

出　　处：《临床肝胆病杂志》2024年第7期1301-1306,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82372603,82172900);中国临床肿瘤学会希思科—朝阳肿瘤研究基金(Y-Young2021-0015)。

摘　　要：神经内分泌肿瘤是一组较罕见的肿瘤性疾病,可发生于身体多种脏器,具有高度肿瘤异质性,常形成以肝脏为最主要受累器官的继发性肿瘤并伴发类癌综合征。肝转移是造成神经内分泌肿瘤患者治疗失败的重要临床事件,通过及时、合理的外科干预有效控制病情发展、争取达到肿瘤无病状态或根治目标,有效延长患者总体生存,是近年来临床医师和研究者聚焦的重要课题。本文综合近年来国内外神经内分泌肿瘤肝转移的外科治疗策略和我国最新诊治指南,并结合笔者实际临床工作经验进行综述和讨论。Neuroendocrine tumors are a group of rare tumor diseases that can occur in various visceral organs of the human body and exhibit significant tumor heterogeneity,and they often lead to secondary tumors mostly involving the liver and carcinoid syndrome.Liver metastasis is an important cause of treatment failure in patients with neuroendocrine tumor,and timely and reasonable surgical interventions that can effectively control disease progression to achieve the disease-free state or the goal of radical treatment and prolong the overall survival of patients has been a focus of research by clinicians and researchers in recent years.With reference to actual clinical work and working experience,this article reviews and discusses the surgical treatment strategies for liver metastasis of neuroendocrine tumors based on related strategies in China and globally and the latest diagnosis and treatment guidelines in China.

关 键 词：神经内分泌瘤 肿瘤转移 肝 外科手术 

分 类 号：R739.4[医药卫生—肿瘤]