肝癌类器官的研究进展  

Research advances in liver cancer organoids

作　　者：赵丽 郭梓琪 杨勇 杨宏新[1] ZHAO Li;GUO Ziqi;YANG Yong;YANG Hongxin(Department of Cell Biology,Inner Mongolia Medical University,Hohhot 010110,China;Department of Abdominal Oncology,Inner Mongolia Autonomous Region People’s Hospital,Hohhot 010017,China)

机构地区：[1]内蒙古医科大学细胞生物学教研室,呼和浩特010110 [2]内蒙古自治区人民医院腹部肿瘤外科,呼和浩特010017

出　　处：《临床肝胆病杂志》2024年第7期1486-1492,共7页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81960772);内蒙古医科大学重点项目(YKD2022ZD016);内蒙古医科大学肿瘤类器官基因编辑转化医学科技创新团队项目;内蒙古自治区自然科学基金(2019MS08087)。

摘　　要：类器官是一种由干细胞或恶性肿瘤自我组装形成并用于临床研究的新型疾病模型,类似于体内的组织与器官,且具有部分功能的3D细胞结构。传统的肝癌模型有两种:一是通过诱导构建动物肝癌模型,即体内模型;二是在体外通过相应细胞系进行细胞学实验研究。类器官集合了传统模型的优点,在肿瘤研究方面具有独特的优势。传统模型由于不能真实反映细胞微环境,常导致与临床研究结果不一致,而新型研究模型的出现,为肝癌研究提供了一个新的方向。本文对肝癌类器官的研究进展进行综述,旨在为今后肝癌研究提供全新的视角。Organoids are a novel disease model that is self-assembled from stem cells or malignant tumors and is used in clinical research.They are similar to tissues and organs in the body and have partially functional 3D cell structures.There are two types of traditional models for liver cancer research,i.e.,in vivo models(animal models of liver cancer established by induction)and in vitro cell experiments using corresponding cell lines.Organoids have the advantages of the two types of traditional models and show unique advantages in tumor research.Traditional models cannot fully reflect the microenvironment of cells,which often leads to the inconsistency with clinical research findings,and the emergence of new research models provides a new direction for the research on liver cancer.This article reviews the research advances in liver cancer organoids,in order to provide a new perspective for future research on liver cancer.

关 键 词：肝肿瘤 类器官 细胞培养技术 

分 类 号：R735.7[医药卫生—肿瘤]