Hp感染与胃癌组织凋亡抑制基因Survivin、MMP-2的表达及其关联性  

Hp Infection and Expressions of Survivin and MMP-2 in Gastric Cancer and Their Correlation

作　　者：陈莉莎 吕晓龙[2] 张亚丽 CHEN Lisha;LV Xiaolong;ZHANG Yali(Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学附属郑州中心医院,450000 [2]信阳职业技术学院,464000

出　　处：《实用癌症杂志》2024年第7期1071-1074,共4页The Practical Journal of Cancer

摘　　要：目的 研究幽门螺杆菌(Hp)感染与胃癌组织凋亡抑制基因存活素(Survivin)、基质金属蛋白酶-2(MMP-2)的表达及其两者的关联性。方法 选取120例胃癌患者为研究对象,采用免疫组化染色法检测癌组织及癌旁组织中Survivin、MMP-2表达,分析其与临床病理特征关系;并检测Hp阳性情况,对比不同感染情况胃癌患者的病理特征及组织凋亡抑制基因Survivin、MMP-2表达,采用Spearman分析Hp感染与Survivin、MMP-2表达的关系。结果 Survivin、MMP-2在胃癌组织中的阳性表达率为76.67%、73.33%,均高于癌旁组织的16.67%和13.33%(P<0.05)。Survivin、MMP-2表达与TNM分期、肿瘤分化程度、肿瘤浸润深度及淋巴结转移有关(P<0.05);与年龄、性别、肿瘤直径无关(P>0.05)。Hp阳性65例,阴性55例。Hp阳性组患者肿瘤分化程度为低-中分化、肿瘤浸润深度及淋巴结转移发生率均高于Hp阴性组(P<0.05),2组年龄、性别、TNM分期、肿瘤直径比较无差异(P>0.05)。Hp阳性组胃癌组织中Survivin、MMP-2阳性表达率为87.69%、83.08%,均高于Hp阴性组的63.64%和61.82%(P<0.05)。Spearman相关分析显示,Hp感染与Survivin、MMP-2表达呈正相关性(γ=0.357、0.349,P<0.05)。结论 Survivin、MMP-2表达均与胃癌发生有关,且Hp感染能够增加胃癌组织凋亡抑制基因Survivin、MMP-2表达。Objective To study Helicobacter pylori(Hp)infection and expressions of survivin and matrix metalloproteinase-2(MMP-2)in gastric cancer,and their correlation.Methods 120 patients with gastric cancer were selected as the research subjects.The expressions of survivin and MMP-2 in cancer tissues and adjacent tissues were detected by immunohistochemical staining,and their relationship with clinicopathological characteristics was analyzed.Hp infection was detected.The pathological characteristics and expressions of survivin and MMP-2 in gastric cancer patients with different infection status were compared.The relationship between Hp infection and expressions of survivin and MMP-2 was analyzed by Spearman method.Results The positive expression rates of survivin and MMP-2 in gastric cancer tissues were 76.67%and 73.33%,significantly higher than those in adjacent tissues(16.67%and 13.33%)(P<0.05).The expressions of survivin and MMP-2 were related to TNM staging,tumor differentiation degree,tumor invasion depth and lymph node metastasis(P<0.05),but not related to age,gender or tumor diameter(P>0.05).There were 65 Hp positive cases and 55 negative cases.The incidence of low-moderate differentiation,tumor invasion depth and incidence of lymph node metastasis in Hp-positive group were higher than those in Hp-negative group(P<0.05).There was no significant difference between the two groups in age,gender,TNM staging,or tumor diameter(P>0.05).The positive expression rates of survivin and MMP-2 in Hp-positive group were 87.69%and 83.08%,significantly higher than those in Hp-negative group(63.64%and 61.82%)(P<0.05).Spearman correlation analysis found that Hp infection was positively correlated with expressions of survivin and MMP-2(γ=0.357,0.349,P<0.05).Conclusion The expressions of survivin and MMP-2 are related to the occurrence of gastric cancer.Hp infection can increase the expressions of survivin and MMP-2 in gastric cancer tissues.

关 键 词：幽门螺杆菌感染 胃癌 存活素 基质金属蛋白酶-2 

分 类 号：R735.2[医药卫生—肿瘤]