循环肿瘤细胞表达与甲状腺癌患者术后淋巴结转移的关系  

The Relationship Between the Expression of Circulating Tumor Cells and Postoperative Lymph Node Metastasis in Patients with Thyroid Cancer

作　　者：杨柳 闫红印 袁宏莉 徐崇娟 YANG Liu;YAN Hongyin;YUAN Hongli(General Hospital of Pingmei Shenma Group,Pingdingshan,467000)

机构地区：[1]平煤神马医疗集团总医院,467000

出　　处：《实用癌症杂志》2024年第7期1145-1148,共4页The Practical Journal of Cancer

摘　　要：目的 探究循环肿瘤细胞(CTCs)表达与甲状腺癌患者术后淋巴结转移的关系。方法 纳入119例拟行甲状腺癌根治术患者为研究对象,于术前、术后7 d对患者CTCs计数以及分型进行检测。术后随访1年,记录所有患者术后淋巴结转移发生情况,将随访期间发生淋巴结转移的患者纳入发生组,将未发生淋巴结转移的患者纳入未发生组。分析CTCs计数以及分型与甲状腺癌患者术后淋巴结转移发生的关系。结果 119例甲状腺癌根治术患者中有7例患者未在外周血中检出CTCs,将其剔除。112例甲状腺癌根治术患者术后发生淋巴结转移41例,占比36.61%(41/112)。2组术后7 d的CTCs计数均较术前提高,发生组患者术前、术后7 d CTCs计数均高于未发生组,差异有统计意义(P<0.05)。发生组术前、术后7 d CTCs分型以单纯间质型为主,占比高于未发生组,差异有统计学意义。基线资料调查显示发生组TNM分期Ⅲ期、术后未辅助化疗者占比高于未发生组,差异有统计学意义。经多因素Logistic回归分析结果显示,TNM分期Ⅲ期、CTCs计数高、单纯间质型CTCs是甲状腺癌患者术后发生淋巴结转移的危险因素(OR>1,P<0.05),术后辅助化疗是患者术后发生淋巴结转移的保护因素(OR<1,P<0.05)。结论 CTCs计数及分型与甲状腺癌患者术后淋巴结转移发生关系密切,CTCs计数高、单纯间质型CTCs是患者术后发生淋巴结转移的危险因素,会增加患者术后淋巴结转移发生风险。Objective To explore the relationship between the expression of circulating tumor cells(CTCs)and postoperative lymph node metastasis in thyroid cancer patients.Methods 119 patients who were scheduled to underwent radical thyroidectomy for thyroid cancer were included as the study subjects,and their CTCs counts and subtypes were detected before and 7 days after surgery.Follow up for 1 year after surgery,the occurrence of lymph node metastasis in all patients were recorded.Patients with lymph node metastasis during the follow-up period were included in the occurrence group,and patients without lymph node metastasis were included in the non-occurrence group.The relationship between the count and classification of CTCs and the occurrence of postoperative lymph node metastasis in patients with thyroid cancer was analyzed.Results CTCs were not detected in the peripheral blood of 7 out of 119 patients with thyroid cancer underwent radical surgery,and were removed.There were 41 cases of lymph node metastasis in 112 patients with thyroid cancer after radical surgery,accounting for 36.61%(41/112).The CTCs count at 7 days after operation in both groups was higher than that before operation.The CTCs count in the patients in the occurrence group was higher than that in the non-occurrence group before and 7 days after operation,with a statistically significant difference(P<0.05).The CTCs in the occurrence group were mainly of simple interstitial type before and 7 days after operation,with a higher proportion than that of the non occurrence group,with a statistically significant difference.The baseline data survey showed that the proportion of patients with TNM stageⅢand postoperative non adjuvant chemotherapy in the occurrence group was higher than that in the non-occurrence group,with a statistically significant difference.Multivariate Logistic regression analysis showed that TNM stageⅢ,high CTCs count and simple interstitial CTCs were risk factors for postoperative lymph node metastasis in patients with thyroid cancer(OR

关 键 词：甲状腺癌 甲状腺癌根治术 循环肿瘤细胞 淋巴结转移 预后 

分 类 号：R736.1[医药卫生—肿瘤]