不同年龄组小细胞肺癌的临床特征与预后影响因素分析  

Clinical Characteristics and Prognostic Factors of Small Cell Lung Cancer in Different Age Groups

作　　者：刘文静 王甘露 LIU Wenjing;WANG Ganlu(Henan Chest Hospital,Zhengzhou,450000)

机构地区：[1]河南省胸科医院,450000

出　　处：《实用癌症杂志》2024年第7期1183-1185,1191,共4页The Practical Journal of Cancer

摘　　要：目的 分析不同年龄组小细胞肺癌(SCLC)患者的临床特征及预后的影响因素。方法 回顾性分析68例SCLC患者的病历有关资料,按患者年龄分为低龄组(<60岁)与高龄组(≥60岁),统计分析2组的临床特征差异。随访1年,按2组的临床结局(生存或死亡)将其分为预后不良组与预后良好组,以多因素Logistic回归分析模型分析影响2组患者预后的因素。结果 2组婚姻状况、家庭收入、有无保险、临床分期相比,差异无统计学意义(P>0.05);高龄组的鳞癌、中心型肺癌占比高于低龄组,差异有统计学意义(P<0.05)。单因素分析显示:婚姻状况、家庭收入、有无保险、临床分期与低龄SCLC患者的预后有关(P<0.05),多因素分析显示:无配偶、家庭收入<5000元、无保险、Ⅲ~Ⅳ期为低龄SCLC患者预后的主要影响因素(P<0.05);单因素分析显示:临床分期与高龄SCLC患者预后有关(P<0.05),多因素分析显示:Ⅲ~Ⅳ期为高龄SCLC患者预后的主要影响因素(P<0.05)。结论 不同年龄组的SCLC患者的临床特征具有一定差异,对于高龄患者其病理类型以鳞癌为主,肿瘤生长部位以中心型肺癌较为多见,且不同年龄组患者预后影响因素亦不尽相同,临床需予以高度重视。Objective To analyze the clinical characteristics and prognostic factors of small cell lung cancer(SCLC)patients in different age groups.Methods A retrospective analysis was conducted on the medical records of 68 SCLC patients,who were divided into a younger group(<60 years old)and an older group(≥60 years old)according to their age.The clinical characteristics of the 2 groups were statistically analyzed.Follow up for 1 year,divide the 2 groups into poor prognosis group and good prognosis group based on their clinical outcomes(survival or death),and analyzed the factors affecting the prognosis of the 2 groups of patients using a multivariate logistic regression analysis model.Results There was no significant difference between the 2 groups in terms of marital status,family income,insurance and clinical stage(P>0.05);The proportion of squamous cell carcinoma and central lung cancer in the elderly group was higher than that in the younger group,and the difference was statistically significant(P<0.05).Univariate analysis showed that marital status,family income,insurance,and clinical stage were significantly related to the prognosis of young patients with SCLC(P<0.05);Multivariate analysis showed that no spouse,family income<5000 yuan,no insurance,stageⅢ~Ⅳwere the main factors affecting the prognosis of young patients with SCLC(P<0.05);Univariate analysis showed that the clinical stage was related to the prognosis of elderly patients with SCLC(P<0.05);Multivariate analysis showed that stageⅢ~Ⅳwas the main prognostic factor of elderly patients with SCLC(P<0.05).Conclusion The clinical characteristics of SCLC patients in different age groups have certain differences.For the elderly patients,the pathological type is mainly squamous cell carcinoma,and the tumor growth site is mainly central lung cancer,and the prognostic factors of patients in different age groups are also different,so clinical attention should be paid to it.

关 键 词：年龄 小细胞肺癌 临床特征 预后 影响因素 

分 类 号：R734.2[医药卫生—肿瘤]