骨肿瘤患者丙泊酚麻醉术后血清IL-1、Lac的表达与肺部感染的关系  

The Relationship Between the Expression of Serum IL-1,Lac and Pulmonary Infection in Patients with Bone Tumor After Propofol Anesthesia

作　　者：王彬 林源 梁超 WANG Bin;LIN Yuan;LIANG Chao(General Hospital of Pingmei Shenma Group,Pingdingshan,467000)

机构地区：[1]平煤神马集团总医院,467000

出　　处：《实用癌症杂志》2024年第7期1204-1206,1213,共4页The Practical Journal of Cancer

摘　　要：目的 探讨骨肿瘤患者丙泊酚麻醉术后血清白介素1(IL-1)、乳酸(Lac)的表达与肺部感染的关系。方法回顾性分析接受手术治疗并行丙泊酚麻醉的80例骨肿瘤患者的临床资料,根据术后肺部感染情况将患者分为感染组(26例)和未感染组(54例)。术后对2组患者血清IL-1、Lac表达水平进行检测,并分析IL-1、Lac表达水平与肺部感染的关系。结果 与未感染组比较,感染组血清IL-1、Lac表达水平明显更高(P<0.05)。与轻度、中度感染组比较,重度感染组血清IL-1、Lac表达水平明显更高;与轻度感染组比较,中度感染组血清IL-1、Lac表达水平明显更高(P<0.05)。血清IL-1、Lac表达水平与轻度、中度、重度肺部感染呈正相关性(P<0.05)。血清IL-1联合Lac检测的灵敏度、特异度明显高于血清IL-1与血清Lac单独检测(P<0.05)。结论 血清IL-1、Lac表达水平与骨肿瘤丙泊酚麻醉术后肺部感染的发生存在一定关联,可根据其表达水平变化情况判断患者的肺部感染严重程度。Objective To investigate the relationship between the expression of serum interleukin-1(IL-1),lactic acid(Lac)and pulmonary infection in patients with bone tumor after propofol anesthesia.Methods The clinical data of 80 patients with bone tumors who underwent surgical treatment and propofol anesthesia were retrospectively analyzed.According to the pulmonary infection,the patients were divided into infection group(26 cases)and non-infection group(54 cases).The expression levels of IL-1 and Lac were detected,and the relationship between the expression levels of IL-1 and Lac and pulmonary infection was analyzed.Results Compared with the uninfected group,the expression levels of serum IL-1 and Lac in the infected group were significantly higher(P<0.05).Compared with the mild and moderate infection groups,the expression levels of serum IL-1 and Lac in the severe infection group were significantly higher;compared with the mild infection group,the expression levels of serum IL-1 and Lac in the moderate infection group were significantly higher(P<0.05).The sensitivity and specificity of serum IL-1+Lac detection were significantly higher than those of serum IL-1 and serum Lac detection(P<0.05).The expression levels of serum IL-1 and Lac were positively correlated with mild,moderate and severe pulmonary infection(P<0.05).Conclusion The expression levels of serum IL-1 and Lac are related to the occurrence of pulmonary infection after bone tumor propofol anesthesia,and the severity of pulmonary infection can be judged according to the changes of their expression levels.

关 键 词：骨肿瘤 丙泊酚麻醉 IL-1 LAC 肺部感染 

分 类 号：R730.7[医药卫生—肿瘤]