经尿道钬激光膀胱肿瘤切除术对表浅层膀胱癌患者血清相关指标及炎症因子的影响  

Effect of Transurethral Holmium Laser Resection of Bladder Tumor on Serum Related Indexes and Inflammatory Factors in Patients with Superficial Bladder Cancer

作　　者：申长发[1] 牛凌卫[1] 白冰[1] SHEN Changfa;NIU Lingwei;BAI Bing(Anyang People's Hospital,Anyang,455000)

机构地区：[1]河南省安阳市人民医院,455000

出　　处：《实用癌症杂志》2024年第7期1207-1209,1217,共4页The Practical Journal of Cancer

摘　　要：目的 探讨经尿道钬激光膀胱肿瘤切除术(HoLRBT)治疗表浅层膀胱癌的临床效果及安全性。方法 选取70例表浅层膀胱癌患者,按随机数字表法分为2组,各35例。对照组行经尿道膀胱肿瘤电切术(TURBT)治疗,观察组行HoLRBT治疗。比较2组手术情况、血清相关指标、炎症因子水平及并发症。结果 观察组膀胱冲洗、尿管留置及住院时间分别为(19.58±2.14)min、(20.34±3.35)d、(8.96±1.15)d,均短于对照组的(32.54±3.49)min、(35.41±4.12)d、(13.75±2.14)d;术中出血量为(26.58±2.35)ml,少于对照组的(40.18±4.27)ml,差异有统计学意义(P<0.05)。观察组术后恶性肿瘤特异生长因子(TSGF)、肝细胞生长因子(HGF)水平分别为(65.36±6.15)U/ml、(2.21±0.32)μmol/L,低于对照组的(80.41±8.36)U/ml、(3.42±0.45)μmol/L,有统计学差异(P<0.05);观察组术后白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)水平分别为(57.25±5.19)pg/ml、(39.39±4.28)pg/ml、(12.25±2.19)mg/L,低于对照组的(64.31±6.28)pg/ml、(45.41±4.38)pg/ml、(15.41±2.23)mg/L,有统计学差异(P<0.05)。观察组并发症较对照组少,有统计学差异(P<0.05)。结论 HoLRBT治疗表浅层膀胱癌效果更佳,可缩短膀胱冲洗、尿管留置时间,减轻手术创伤,降低TSGF、HGF水平,且并发症少。Objective To investigate the clinical efficacy and safety of transurethral holmium laser resection of bladder tumors(HoLRBT)for superficial bladder cancer.Methods 70 cases of superficial bladder cancer were randomly divided into 2 groups,35 cases in each group.The control group received transurethral resection of bladder tumors(TURBT)treatment,while the observation group received HoLRBT treatment.Compare the surgical conditions,serum related indicators,levels of inflammatory factors,and complications between the 2 groups.Results The bladder irrigation,indwelling catheter,and hospitalization time in the observation group were(19.58±2.14)minutes,(20.34±3.35)days,and(8.96±1.15)days,which were shorter than those in the control group(32.54±3.49)minutes,(35.41±4.12)days,and(13.75±2.14)days;The intraoperative bleeding volume was(26.58±2.35)ml,which was lower than the control group's(40.18±4.27)ml,and the difference was statistically significant(P<0.05).The postoperative levels of malignant tumor specific growth factor(TSGF)and hepatocyte growth factor(HGF)in the observation group were(65.36±6.15)U/ml and(2.21±0.32)μMol/L,respectively,lower than the control group's(80.41±8.36)U/ml,(3.42±0.45)μMol/L,with statistical difference(P<0.05);Postoperative interleukin-6(IL-6)and tumor necrosis factor in the observation group-α(TNF)-α The levels of C-reactive protein(CRP)were(57.25±5.19)pg/ml,(39.39±4.28)pg/ml,and(12.25±2.19)mg/L,which were lower than the control group's(64.31±6.28)pg/ml,(45.41±4.38)pg/ml,and(15.41±2.23)mg/L,with statistical differences(P<0.05).The observation group had fewer complications compared to the control group,with a statistical difference(P<0.05).Conclusion HoLRBT is more effective in the treatment of superficial bladder cancer,which can shorten the time of bladder flushing and catheter indwelling,reduce the surgical trauma,reduce the levels of TSGF and HGF,and have fewer complications.

关 键 词：膀胱癌 经尿道钬激光切除术 经尿道电切术 炎症因子 并发症 

分 类 号：R737.14[医药卫生—肿瘤]