polo样激酶1、RNA聚合酶Ⅱ亚基A在人脑胶质瘤中的表达及与预后的关系  

Expression of polo like kinase 1 and RNA polymerase II subunit A in human brain glioma and their relationship with prognosis

作　　者：覃重桥[1] 姜又胜 朱华泉 QIN Zhongqiao;JIANG Yousheng;ZHU Huaquan(Department of Neurosurgery,Guigang City People’s Hospital,Guigang 537100,Guangxi,China)

机构地区：[1]贵港市人民医院神经外科,广西贵港5371000

出　　处：《癌症进展》2024年第11期1196-1199,1246,共5页Oncology Progress

基　　金：广西壮族自治区科研基金项目(2021KJ0152)。

摘　　要：目的 探讨polo样激酶1(PLK1)、RNA聚合酶Ⅱ亚基A(POLR2A)在人脑胶质瘤(BG)中的表达及与预后的关系。方法 选取86例BG患者作为观察组,另选取30例非肿瘤脑疾病患者作为参照组,收集观察组患者的BG组织和参照组患者的非肿瘤脑组织。比较两组患者PLK1、POLR2A表达情况和不同临床特征BG患者的BG组织中PLK1、POLR2A的阳性表达情况;比较不同PLK1、POLR2A表达情况BG患者的生存情况;采用Cox回归模型分析BG患者预后的影响因素。结果 观察组患者PLK1、POLR2A阳性表达率分别高于参照组,差异均有统计学意义(P﹤0.05)。低分化BG患者的BG组织中PLK1、POLR2A阳性表达率均高于中高分化患者,差异均有统计学意义(P﹤0.05)。PLK1、POLR2A阳性表达患者的中位生存时间均明显短于PLK1、POLR2A阴性表达患者,差异均有统计学意义(P﹤0.01)。Cox多因素回归分析结果显示,低分化、PLK1阳性表达、POLR2A阳性表达均为BG患者预后的独立危险因素(P﹤0.05)。结论 BG患者PLK1、POLR2A呈高表达,PLK1、POLR2A高表达BG患者中位生存时间缩短,低分化、PLK1阳性表达、POLR2A阳性表达均为BG患者预后的独立危险因素。Objective To investigate the expression of polo like kinase 1(PLK1) and RNA polymerase II subunit A(POLR2A) in human brain glioma(BG) and their relationship with prognosis.Method A total of 86 patients with BG were selected as the observation group and 30 non-tumor brain disease patients as the reference group.The BG tissues of the observation group and the non-tumor brain tissues of the reference group were collected.The expressions of PLK1and POLR2A in the two groups and the positive expressions of PLK1 and POLR2A in BG tissues of BG patients with different clinical characteristics were compared.The survival of BG patients with different PLK1 and POLR2A expressions were compared.Cox regression model was used to analyze the prognostic influencing factors of BG patients.Result The positive expression rates of PLK1 and POLR2A in observation group were higher than those in reference group,the differences were statistically significant(P<0.05).The positive expression rates of PLK1 and POLR2A in BG tissues of BG patients with poorly differentiated were higher than those of BG patients with medium-high differentiated,and the differences were statistically significant(P<0.05).The median survival time of patients with positive expressions of PLK1and POLR2A were significantly shorter than those of patients with negative expressions of PLK1 and POLR2A,the differences were statistically significant(P<0.01).Cox multivariate regression analysis showed that low differentiation,PLK1 positive expression and POLR2A positive expression were independent risk factors for prognosis of BG patients(P<0.05).Conclusion PLK1 and POLR2A are highly expressed in BG patients,and the median survival time of BG patients with high expression of PLK1 and POLR2A are shortened.Low differentiation,positive expression of PLK1 and positive expression of POLR2A are independent risk factors for prognosis of BG patients.

关 键 词：POLO样激酶1 RNA聚合酶Ⅱ亚基A 脑胶质瘤 预后 

分 类 号：R739739.4141[医药卫生—肿瘤]