肿瘤特异性生长因子、碱性磷酸酶、甲胎蛋白在乳腺癌中的表达及对术后复发的预测价值  

Expression of tumor specific growth factor,alkaline phosphatase and α-fetal protein in breast cancer and their predictive value for postoperative recurrence

作　　者：贾梅香 秦柯君 高士凯 JIA Meixiang;QIN Kejun;GAO Shikai(Department of Laboratory,Xinxiang Central Hospital/the Fourth Clinical College of Xinxiang Medical College,Xinxiang 453000,He’nan,China)

机构地区：[1]新乡市中心医院/新乡医学院第四临床学院检验科,河南新乡4530000

出　　处：《癌症进展》2024年第11期1252-1255,共4页Oncology Progress

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200949)。

摘　　要：目的 探讨肿瘤特异性生长因子(TSGF)、碱性磷酸酶(ALP)、甲胎蛋白(AFP)在乳腺癌中的表达及对术后复发的预测价值。方法 对120例乳腺癌患者进行为期6个月的随访,根据术后是否复发分为复发组18例和未复发组102例。比较两组患者血清TSGF、ALP、AFP水平;乳腺癌术后复发的影响因素采用Logistic回归分析;绘制受试者工作特征(ROC)曲线,分析血清TSGF、ALP、AFP对乳腺癌术后复发的预测效能。结果 复发组患者血清TSGF、ALP、AFP水平均明显高于未复发组患者,差异均有统计学意义(P﹤0.01)。Logistic回归分析结果显示,TSGF、ALP、AFP、临床分期、淋巴结转移、脉管侵犯均为乳腺癌术后复发的影响因素(P﹤0.05)。血清TSGF、ALP、AFP联合检测预测乳腺癌术后复发的曲线下面积(AUC)为0.841,大于TSGF、ALP、AFP单独检测的0.796、0.715、0.680。结论 乳腺癌术后复发患者血清TSGF、ALP、AFP水平升高,血清TSGF、ALP、AFP联合检测预测乳腺癌术后复发的价值较高。Objective To investigate the expression of tumor specific growth factor(TSGF),alkaline phosphatase(ALP) and α-fetal protein(AFP) in breast cancer and their predictive value for postoperative recurrence.Method A total of 120 patients with breast cancer were followed up for 6 months,and were divided into recurrence group(18 cases) and non-recurrence group(102 cases) according to postoperative recurrence.Serum TSGF,ALP and AFP levels were compared between the two groups.The influencing factors of postoperative recurrence of breast cancer were analyzed by Logistic regression.Receiver operating characteristic(ROC) curve was drawn to analyze the predictive efficacy of serum TSGF,ALP and AFP for postoperative recurrence of breast cancer.Result The serum TSGF,ALP and AFP levels in the recurrence group were significantly higher than those in the non-recurrence group,the differences were statistically significant(P<0.01).Logistic regression analysis showed that TSGF,ALP,AFP,clinical stage,lymph node metastasis and vascular invasion were influencing factors of postoperative recurrence of breast cancer(P<0.05).The area under the curve(AUC) of combined detection of TSGF,ALP and AFP for predicting postoperative recurrence of breast cancer was 0.841,which was greater than that of TSGF,ALP and AFP alone detection(0.796,0.715 and 0.680).Conclusion Serum TSGF,ALP and AFP levels are elevated in postoperative recurrence patients with breast cancer,and the combined detection of TSGF,ALP and AFP has highly value in predicting postoperative recurrence of breast cancer.

关 键 词：乳腺癌 肿瘤特异性生长因子 碱性磷酸酶 甲胎蛋白 复发 

分 类 号：R737737.9[医药卫生—肿瘤]