微生态制剂对非酒精性脂肪性肝炎患者临床作用的研究  

Study on the clinical effect of microecologics on patients with nonalcoholic steatohepatitis

作　　者：刘东林[1] 汪照函[1] 陈朋果 王爱瑶[1] 吴向东 陈建勇[1] LIU Donglin;WANG Zhaohan;CHEN Pengguo;WANG Aiyao;WU Xiangdong;Chen Jianyong(Department of Gastroenterology,Jiangxi Provincial People's Hospital,Nanchang 330006;Department of Gastroenterology,Xinjian Hospital of Traditional Chinese Medicine,Nanchang 330000)

机构地区：[1]江西省人民医院南昌医学院第一附属医院消化内科,南昌330006 [2]南昌市新建区中医院消化内科,南昌330000

出　　处：《江西医药》2024年第4期340-344,共5页Jiangxi Medical Journal

基　　金：江西省自然科学基金,编号20171BAB205011。

摘　　要：目的 观察微生态制剂辅助治疗非酒精性脂肪性肝炎(NASH)患者的临床效果。方法 将我院2019年1月至2020年1月门诊及住院的诊断为NASH的102例患者纳入研究,随机分为对照组和治疗组。所有患者均通过结构化方案改变生活方式,采用饮食治疗和运动治疗相结合的策略。治疗组患者另外口服微生态制剂(枯草杆菌肠球菌二联活菌胶囊),比较两组患者治疗前后体质量指数、腰围、脂肪肝程度、肝酶、空腹血糖(FPG)、血脂指标、肿瘤坏死因子-α(TNF-α)、内毒素(LPS)水平。结果 治疗后两组患者体质量指数、腰围均明显降低,脂肪肝程度亦有明显好转,但治疗组与对照组无显著差异。空腹血糖、血清肝酶、血脂、TNF-α、LPS水平均低于治疗前,且治疗组与对照组亦有显著差异,差异均有统计学意义(P<0.05)。结论 微生态制剂枯草杆菌肠球菌二联活菌胶囊治疗NASH可显著改善脂肪肝程度及肝功能、血脂指标及降低内毒素、炎症因子等,值得临床推广应用。Objective To observe the clinical effect of microecologics in the adjuvant treatment of non-alcoholic steatohepatitis(NASH).Methods 102 patients diagnosed with NASH in our hospital from January 2019 to January 2020 were included in the study and randomly divided into control group and treatment group.All patients underwent lifestyle changes through a structured regimen that combined diet therapy with exercise therapy.Patients in the treatment group also took oral microecological preparation(Bacillus subtilis enterococcus capsules),and the levels of body mass index,waist circumference,fatty liver,liver enzymes,fasting blood glucose(FPG),lipid indexes,tumor necrosis faction-α(TNF-α) and endotoxin(LPS) before and after treatment were compared between the two groups.Results After treatment,the body mass index and waist circumference of the two groups were significantly reduced,and the degree of fatty liver was also significantly improved,but there was no significant difference between the treatment group and the control group.The levels of fasting blood glucose,serum liver enzyme,lipid,TNF-α and LPS were lower than before treatment,and there were significant differences between treatment group and control group,with statistical significance(P < 0.05).Conclusion The microecological preparation of Enterococcus subtilis combined with viable bacteria capsule can significantly improve the degree of fatty liver,liver function,lipid indexes and reduce endotoxin and inflammatory factors in the treatment of NASH,which is worthy of clinical application.

关 键 词：非酒精性脂肪性肝炎 微生态制剂 枯草杆菌肠球菌二联活菌胶囊 肝功能 血脂 

分 类 号：R575.5[医药卫生—消化系统]