肺癌细胞中GTSE1与细胞周期的关系及潜在调控机制  

Relationship between GTSE1 and Cell Cycle and Potential Regulatory Mechanisms in Lung Cancer Cells

作　　者：王传林 徐佳丽 刘明珠 刘佳宇 黄云超[3] 周岚[1] Chuanlin WANG;Jiali XU;Mingzhu LIU;Jiayu LIU;Yunchao HUANG;Lan ZHOU(Department of Clinical Nutrition,The Third Affiliated Hospital of Kunming Medical University,Yunnan Tumor Hospital,Kunming 650118,China;Department of Health Toxicology,School of Public Health,Anhui Medical University,Hefei 230032,China;Department of Chest Surgery,The Third Affiliated Hospital of Kunming Medical University,Yunnan Tumor Hospital,Kunming 650118,China)

机构地区：[1]昆明医科大学第三附属医院,云南省肿瘤医院临床营养科,昆明650118 [2]安徽医科大学公共卫生学院卫生毒理学系,合肥230032 [3]昆明医科大学第三附属医院,云南省肿瘤医院胸外科,昆明650118

出　　处：《中国肺癌杂志》2024年第6期451-458,共8页Chinese Journal of Lung Cancer

基　　金：国家自然科学基金项目(No.82360562);昆明医科大学研究生创新基金项目(No.2023S354)资助。

摘　　要：细胞周期的调控对于维持细胞正常功能至关重要,尤其在肺癌等疾病的发展中。细胞周期由四个主要阶段组成(G1、S、G2和M期),这些阶段通过一系列精确的分子事件来确保细胞正确增殖和分裂。在肺癌细胞中,细胞周期失调可导致癌细胞无序增殖和侵袭能力增强。G2和S期表达-1(G2and S-phase expressed 1,GTSE1)是一种在细胞质中发现的调节蛋白,它在多种癌细胞的细胞周期分布中起着关键作用,并参与了细胞增殖和凋亡等过程。GTSE1通过与细胞周期蛋白依赖激酶抑制因子1A(cyclin-dependent kinase inhibitor 1A,p21)的相互作用,维持p21的稳定性,进而抑制细胞周期蛋白依赖性激酶1/2(cyclin-dependent kinase 1/2,CDK1/2)的活性,影响细胞周期的进程。此外,GTSE1还参与肿瘤蛋白53(tumor protein 53,p53)信号通路的调控。在双微体同源基因2(mouse double minute 2 homolog,MDM2)的协助下,GTSE1能够将p53从细胞核转运至胞质,并促进其泛素化降解,从而影响细胞周期和细胞死亡相关信号通路。本文综述了GTSE1在肺癌细胞中的表达情况和对肺癌的影响,以及其参与细胞周期调控的潜在机制。The regulation of the cell cycle is essential for maintaining normal cellular function,especially in the development of diseases such as lung cancer.The cell cycle consists of four major phases(G1,S,G2 and M phases),which are characterized by a series of precise molecular events to ensure proper cell proliferation and division.In lung cancer cells,cell cycle dysregulation can lead to disordered proliferation and increased invasiveness of cancer cells.G2 and S-phase expressed 1(GTSE1)is a regulatory protein found in the cytoplasm of the cell,which plays a key role in the cell cycle distribution of a wide range of cancer cells and is involved in life processes such as cell proliferation and apoptosis.GTSE1 affects cell cycle progression by interacting with cyclin-dependent kinase inhibitor 1A(p21)and maintaining the stability of p21,which in turn inhibits the activity of cyclin-dependent kinase 1/2(CDK1/2).In addition,GTSE1 is also involved in the regulation of tumor protein 53(p53)signaling pathway.With the assistance of mouse double minute 2 homolog(MDM2),GTSE1 is able to transport p53 from the nucleus to the cytoplasm and promote its ubiquitination and degradation,thus affecting cell cycle and cell deathrelated signaling pathways.This paper reviews the expression of GTSE1 in lung cancer cells and its effects on lung cancer,as well as its potential mechanisms involved in cell cycle regulation.

关 键 词：肺肿瘤 细胞周期 GTSE1 细胞周期调节因子 

分 类 号：R734.2[医药卫生—肿瘤]