Emerging insights into the function of very long chain fatty acids at cerebellar synapses  

作　　者：Martin-Paul Agbaga Mohiuddin Ahmad 

机构地区：[1]Department of Cell Biology and Ophthalmology,University of Oklahoma Health Sciences Center,and Dean McGee Eye Institute,Oklahoma City,OK,USA

出　　处：《Neural Regeneration Research》2025年第6期1709-1710,共2页中国神经再生研究（英文版）

基　　金：supported by NEI/NIH R01 EY030513;NIAMS/NIH R21-AR076035;Multi-PI Team Science grant from Presbyterian Health Foundation。

摘　　要：Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).

关 键 词：FUNCTIONS function INSIGHT 

分 类 号：R338[医药卫生—人体生理学]