吸烟和轻中度饮酒与社区老年男性认知功能相关性研究  

A study on the correlation between smoking,light to moderate alcohol consumption,and cognitive function in elderly men in the community

作　　者：李斌[1] 李永超[1] 宋燕[1] 李霞[2] 肖世富[2] 孙琳 LI Bin;LI Yongchao;SONG Yan;LI Xia;XIAO Shifu;SUN Lin(Shanghai Mental Health Center,Shanghai Jiaotong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海市杨浦区精神卫生中心,上海200090 [2]上海交通大学医学院附属精神卫生中心

出　　处：《中国神经精神疾病杂志》2024年第4期221-226,共6页Chinese Journal of Nervous and Mental Diseases

基　　金：上海健康医学院精神卫生临床研究中心项目(编号:20MC2020005);上海市杨浦区科研项目(编号:YPM202114)。

摘　　要：目的探讨吸烟和轻中度饮酒与社区老年男性认知功能的相关性。方法采用中国纵向老龄队列数据库,纳入其中1201名社区老年男性(不含重度饮酒者),根据自我汇报的吸烟饮酒史将其分为吸烟饮酒组(n=332)、不吸烟但饮酒组(n=126)、吸烟但不饮酒组(n=308)、不吸烟不饮酒组(n=435),应用北京版蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)评估认知功能。采用双因素方差分析比较认知功能的差异,多因素线性回归模型分析认知功能下降的风险因素。结果主效应分析提示,轻中度饮酒对MoCA总分(F=6.076,P=0.014)、MoCA命名(F=11.179,P=0.001)和MoCA抽象(F=7.718,P=0.006)的影响具有统计学意义,轻中度饮酒者比不饮酒者的MoCA总分(22.50±5.27 vs.23.30±5.28)、MoCA命名(2.41±0.85 vs.2.58±0.76)、MoCA抽象(0.93±0.84 vs.1.10±0.82)更低。吸烟对MoCA总分(F=0.234,P=0.628)、MoCA命名(F=0.110,P=0.741)和MoCA抽象(F=1.335,P=0.248)的影响无统计学意义,吸烟和轻中度饮酒对MoCA评分的影响不存在交互作用(P>0.05)。多因素线性回归分析结果显示,无轻中度饮酒史与MoCA命名呈正相关(B=0.125,P=0.008)。对非痴呆者进行分层分析显示,无轻中度饮酒史与MoCA总分(B=0.550,P=0.011)、MoCA命名(B=0.134,P=0.002)呈正相关。结论吸烟和轻中度饮酒对社区老年男性认知功能无明显的相互影响,轻中度饮酒可能与总体认知功能和命名功能下降相关。Objective To explore the correlation between smoking,light to moderate alcohol consumption and cognitive function in elderly men in the community.Methods One thousand two hundred one elderly men(excluding heavy drinkers)from the Chinese longitudinal aging cohort database were selected and divided into smoking and drinking group(n=332),non-smoking but drinking group(n=126),smoking but non-drinking group(n=308),and non-smoking and non-drinking group(n=435)based on self-provided smoking and drinking information.Cognitive function was evaluated using the Beijing version of the Montreal cognitive assessment(MoCA).A two factor ANOVA and a multiple factor linear regression model were used to analyze differences in cognitive function,and risk factors for cognitive decline,respectively.Results The main effect analysis indicated that light to moderate alcohol consumption had a statistically significant impact on MoCA total score(F=6.076,P=0.014),MoCA naming(F=1.179,P=0.001),and MoCA abstraction(F=7.718,P=0.006).Light to moderate drinkers had lower MoCA total score(22.50±5.27 vs.23.30±5.28),MoCA naming(2.41±0.85 vs.2.58±0.76),and MoCA abstraction(0.93±0.84 vs.1.10±0.82)compared to non-drinkers.The main effects of smoking on MoCA total score(F=0.234,P=0.628),MoCA naming(F=0.110,P=0.741),and MoCA abstraction(F=1.335,P=0.248)were not significant.There was no interaction between smoking and light to moderate alcohol consumption on MoCA score(P>0.05).The results of multiple factor linear regression analysis showed a positive correlation(B=0.125,P=0.008)between no history of light to moderate alcohol consumption and MoCA naming.A stratified analysis of non-dementia individuals showed a positive correlation between a history of light to moderate alcohol consumption and MoCA total score(B=0.550,P=0.011)and MoCA naming(B=0.134,P=0.002).Conclusion Smoking and light to moderate alcohol consumption have no significant mutual effect on cognitive function in elderly men in the community,while light to moderate alcohol consumption m

关 键 词：吸烟行为 饮酒行为 老年男性 命名功能 认知功能 危险因素 相关性研究 

分 类 号：R749.16[医药卫生—神经病学与精神病学]