老年与中青年抑郁障碍患者非酶抗氧化物水平差异  

Differences in non-enzymatic antioxidant levels between later-life depression and younger depression

作　　者：范宁[1] 张琪 白璐源 赵文暄 云雅君 燕江陵[1] 韩笑乐[1] 杨甫德[1] FAN Ning;ZHANG Qi;BAI Luyuan;ZHAO Wenxuan;YUN Yajun;YAN Jiangling;HAN Xiaole;YANG Fude(Beijing Huilongguan Hospital,Beijing 100096,China)

机构地区：[1]北京回龙观医院老年科,北京100096 [2]无锡市精神卫生中心 [3]北京回龙观医院药学部,北京100096 [4]北京回龙观医院中西医结合科,北京100096 [5]北京回龙观医院心理科,北京100096

出　　处：《中国神经精神疾病杂志》2024年第4期227-231,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：北京市科技计划(编号:Z211100003521016);北京市医管局“培育”计划(编号:PX2024072);北京回龙观医院青年科研基金(编号:LY202201)。

摘　　要：目的探索不同年龄阶段抑郁障碍患者非酶抗氧化物水平的差异。方法纳入抑郁障碍患者135例(包括年龄≥60岁的老年抑郁组63例和<60岁的中青年抑郁组72例),健康对照98名(包括年龄≥60岁的老年对照组46名和<60岁的中青年对照组52名)。测定被试血清非酶抗氧化物尿酸、总胆红素和白蛋白水平。结果双因素方差分析表明,对于尿酸、总胆红素水平,抑郁因素主效应均有统计学意义(P<0.05),抑郁障碍患者的尿酸[(314.30±85.18)μmol/L vs.(339.68±85.27)μmol/L]、总胆红素[(12.81±6.16)μmol/L vs(.15.09±5.97)μmol/L]水平低于对照(P<0.05)。年龄分组与抑郁因素对白蛋白水平的影响存在交互作用(F=11.059,P<0.001),老年抑郁组患者的白蛋白[(41.05±3.97)g/L vs.(46.01±4.49)g/L]水平低于中青年抑郁组患者(P<0.01)。结论抑郁障碍患者存在非酶类抗氧化物的异常,老年患者的损害更为突出。Objective This study aimed to investigate the levels of non-enzymatic antioxidants among patients with depression at different age stages.Methods One hundred thirty five patients with depression(including 63 elderly patients aged 60 years and older,and 72 young and middle-aged patients under 60 years old)and 98 healthy controls(including 46 elderly controls aged 60 years and older,and 52 young and middle-aged controls aged under 60 years old)were enrolled.Serum levels of non-enzymatic antioxidants(uric acid,total bilirubin,albumin)were assessed.Results Multiple analysis of variance showed the main effects of depression factors on uric acid and total bilirubin were significant(P<0.05).Uric acid[(314.30±85.18)μmol/L vs.(339.68±85.27)μmol/L],total bilirubin[(12.81±6.16)μmol/L vs.(15.09±5.97)μmol/L]levels were lower in patients with depression than in controls(P<0.05).There was an interactive effect between age and depression factors on the levels of albumin(P<0.001),and the levels of albumin[(41.05±3.97)g/L vs.(46.01±4.49)g/L]were lower in group of the elderly patients with depression than those in group of the young and middle-aged patients with depression(P<0.01).Conclusion Patients with depression have abnormalities in levels of non-enzymatic antioxidants which are more severe in elderly patients.

关 键 词：抑郁症 老年人 非酶抗氧化物 尿酸 胆红素 白蛋白 

分 类 号：R749.4[医药卫生—神经病学与精神病学]