脑小血管病影像学标志物与认知功能障碍相关性研究进展  

Research progress on the correlation between imaging markers and cognitive dysfunction in cerebral small vessel disease

作　　者：邢楠 华素玉 李俐涛[2] XING Nan;HUA Suyu;LI Litao(Graduate School,North China University of Science and Technology,Tangshan 063210,China;Department of Neurology,Hebei General Hospital,Shijiazhuang 050051,China)

机构地区：[1]华北理工大学研究生院,唐山063210 [2]河北省人民医院神经内六科

出　　处：《中国神经精神疾病杂志》2024年第4期242-246,共5页Chinese Journal of Nervous and Mental Diseases

基　　金：河北省自然科学基金资助项目(编号:H2022307073)。

摘　　要：脑小血管疾病(cerebral small vessel disease,CSVD)的部分患者会出现认知功能下降并可能进展为痴呆,严重降低患者的生活质量。目前关于CSVD影像学标志物与认知功能障碍的相关性研究表明,脑白质高信号、血管周围间隙扩大、脑微出血、腔隙性脑梗死的分布位置、严重程度对各认知域产生不同影响,CSVD导致的认知功能障碍可能与炎症因子间接影响和脑组织纤维束破坏等机制相关。但CSVD影像学标志物与认知功能的关系及其相关机制还需要更进一步研究加以验证。Some patients with cerebral small vessel disease(CSVD)may experience cognitive decline and may progress to dementia,which seriously impairs the quality of life of patients.Current studies on the correlation between CSVD imaging markers and cognitive impairment have shown that the distribution and severity of white matter hyperintensity(WMH),enlarged perivascular spaces(EPVS),cerebral microbleeds(CMB),and lacunar infarction(LI)have different effects on various cognitive domains.The cognitive dysfunction caused by CSVD may be related to indirect effects of inflammatory factors and damage to the brain tissue fiber bundles.However,the relationship between CSVD imaging markers and cognitive function and its related mechanisms still need to be further studied and verified.

关 键 词：脑小血管病 影像学标志物 脑白质高信号 血管周围间隙扩大 脑微出血 腔隙性梗死 认知功能 

分 类 号：R743[医药卫生—神经病学与精神病学] R749.1[医药卫生—临床医学]