Fully umbilical cord-derived adhesive materials enable to recruit and segregate immune cells for the reversal of acute liver failure  

作　　者：Xiao Yi Feng Chen Kunjie Gao Huayan Li Yuan Xie Shao Li Jiajun Zhang Qing Peng Weijie Zhou Shutao Wang Jun-Bing Fan Yi Gao 

机构地区：[1]Research Centre for Artificial Organ and Tissue Engineering&Institute of Regenerative Medicine Department of Hepatobiliary Surgery II Zhujiang Hospital,Cancer Research Institute,School of Basic Medical Sciences,Southern Medical University,Guangzhou,Guangdong Province 510515,P R China [2]Department of Gynecology,Zhujiang Hospital,Southern Medical University,Guangzhou 510515,P R China [3]CAS Key Laboratory of Bio-inspired Materials and Interfacial Science,CAS Center for Excellence in Nanoscience,Technical Institute of Physics and Chemistry,Chinese Academy of Sciences,Beijing 100190,P R China [4]Department of Hepato-Biliary-Pancreatic and Hernia Surgery,The First People’s Hospital of Zhaoqing,Zhaoqing,Guangdong 526000,P R China [5]Department of Pathology,School of Basic Medical Sciences,Southern Medical University,Guangzhou 510515,P R China

出　　处：《Engineered Regeneration》2024年第1期70-79,共10页再生工程（英文）

基　　金：support by the National Key R&D Program of China (2022YFA1104900,2022YFA0806301);the National Natural Science Foundation of China (22075127,31972926,82371725,and 32301204);the Guangdong Key Research and Develop-ment Plan (2019B020234003).

摘　　要：Inflammatory cytokine storms can trigger disease exacerbation and even death and have reached a consensus in the clinical treatment of acute organ failure.However,the existing strategies remain a great challenge to efficiently suppress inflammatory cytokine storms for promoting organ repair and regeneration.Herein,fully human umbilical cord(UC)-derived adhesive materials(UCAM)that integrate decellularized extracellular matrix(ECM)nanofiber hydrogel and homologous mesenchymal stem cells(MSCs)are demonstrated to greatly suppress inflammatory cytokine storms,demonstrating high efficacy in treating acute liver failure(ALF)in rats with 90%hepatectomy.The UC-derived adhesive materials have the capacity to secrete a significant quantity of cytokines by MSCs to recruit activated immune cells to migrate into their ECM nanofiber networks,segregating them away from the infection area and thereby greatly suppressing the inflammatory cytokine storms.As expected,the UC-derived adhesive materials can significantly promote hepatocyte proliferation to achieve functional recovery and regeneration of the liver,significantly improving the survival rate in rats.Our fully human UC-derived adhesive materials provide a new avenue in suppressing inflammatory cytokine storms for promoting organ regeneration that would be really utility in clinical organ transplantation-related treatment.

关 键 词：Interfacial adhesive materials Extracellular matrix nanofibers HYDROGEL Mesenchymal stem cells Acute liver failure 

分 类 号：R575.3[医药卫生—消化系统]