The role of Piezo1 and Piezo2 proteins in tissue engineering:A Comprehensive review  

作　　者：Tejaswini Tadge Ashwini Pattewar Namdev More Srivalliputtur Sarath Babu Ravichandiran Velyutham Govinda Kapusetti 

机构地区：[1]National Institute of Pharmaceutical Education and Research,Kolkata,West Bengal 700054,India [2]National Institute of Pharmaceutical Education and Research,Ahmedabad,Gujarat 382355,India

出　　处：《Engineered Regeneration》2024年第2期170-185,共16页再生工程（英文）

摘　　要：Almost every life form,from the tiniest bacterium to humans,is mechanosensitive,implying it can use mechani-cal stresses to trigger certain physiological responses in the form of electric signals.Mechanotransduction largely relies on ion channels that respond to mechanical forces,such as the epithelial sodium channels/degenerins,tran-sient receptor potential channel,and the two-pore domain potassium channel.Piezo1 and Piezo2 proteins were discovered to be the biggest non-selective mechanosensitive cation channels in the cell membrane.A substantial amount of research has previously been published on the Piezo channel’s function in touch sensation,balance,and cardiovascular regression.However,the mechanistic perspective must be refined to fully understand the role of Piezo proteins in tissue engineering.This review centers on the latest insights into the structure of Piezo chan-nels,activation mechanisms,and its interactions with cytoskeletal components,by emphasizing the physiological activities of Piezo channels in different tissues.The study also places focus on the possibilities of targeting this cation channel family as a tissue regeneration aid.

关 键 词：Piezo1 Piezo2 MECHANOTRANSDUCTION Tissue regeneration MECHANORECEPTORS 

分 类 号：R318[医药卫生—生物医学工程]