104例产前死胎原因的临床分析与探讨  

Clinical Analysis and Discussion on the Causes of 104 Cases of Prenatal Stillbirth

作　　者：王链链 杨玲[1] 顾宁[1] 柳华[1] 王志群[1] 戴毅敏[1] WANG Lianlian;YANG Ling;GU Ning(Department of Obstetrics and Gynecology,Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing Jiangsu 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院妇产科,江苏南京210008

出　　处：《实用妇产科杂志》2024年第6期486-489,共4页Journal of Practical Obstetrics and Gynecology

摘　　要：目的:分析产前死胎原因的临床资料,以增加对死胎原因的认识。方法:收集2018年1月至2022年12月在南京大学医学院附属鼓楼医院终止妊娠的产前死胎病例,分析其临床资料的分布特征及死胎原因分布,采用美国死胎协作网络(SCRN)开发的标准进行死因归类,并分为死因明确组和死因不明组,比较分析两组人群的不同特征。结果:研究期间共有产前死胎210例,符合纳入标准者共104例。其中有尸检结果的为33例(31.7%),39例(37.5%)有遗传学结果,具有胎盘病理学检查的有75例(72.1%)。经SCRN标准归类分级后,死因归入很可能有关者55例(52.9%),可能有关者33例(31.7%),可能无关者13例(12.5%),还有3例(2.9%)不能归因,即死因明确组占84.6%(88例),死因不明组占15.4%(16例)。死因明确组与死因不明组相比,前者胎盘病理学检查率显著增高(78.4%)。死因分类中,胎盘病理性改变占比最多,占26.9%(28例),其次是妊娠合并症占比25.0%(26例),有15.4%的死胎原因仍是不明原因。结论:胎盘病理学检查对明确死胎原因有重要意义,采用SCRN的死胎病因分类分级法具有可行性,胎盘病理性改变在死胎原因分类中占比较高,建议每一例死胎胎盘都要进行病理学检查。Objective:The clinical data of prenatal stillbirth were analyzed in order to increase the understand-ing of the causes of stillbirth.Methods:Prenatal stillbirth cases that terminated pregnancy in Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University from January 2018 to December 2022 were col-lected,and the distribution characteristics of clinical data and the stillbirth causes were analyzed.The causes of death were classified according to the standards developed by the Stillbirth Collaborative Research Network(SCRN)in the United States,and they were divided into clear cause-of-death group and unknown cause-of-death group.The different characteristics of the two groups were compared and analyzed.Results:There were 210 ca-ses of prenatal stillbirth during the study period,and 104 cases met the inclusion criteria.Among them,33 cases(31.7%)had autopsy results,39 cases(37.5%)had genetic results,and 75 cases(72.1%)had placental pathol-ogy.According to the classification of SCRN standard,55 cases(52.9%)were probably related to the cause of death,33 cases(31.7%)were classified as possible,13 cases(12.5%)were probably unrelated,and 3 cases(2.9%)could not be attributed to the cause of death,that is,84.6%(88 cases)in the clear cause of death group and 15.4%(16 cases)in the unknown cause of death group.The rate of placental pathological examination in the clear cause of death group was significantly higher than that in the unknown cause of death group(78.4%).In the classification of causes of death,placental pathological changes accounted for the largest proportion,account-ing for 26.9%(28 cases),followed by pregnancy complications accounting for 25.0%(26 cases),and 15.4%of the cases were still unexplained.Conclusions:Placental pathology is of great significance for clarifying the cause of stillbirth.It is feasible to use SCRN to classify the etiology of stillbirth.Pathological placental conditions account for a relatively high proportion in the classification of stillbirth causes.It is recomm

关 键 词：死胎 死胎原因 尸检 遗传学诊断 胎盘病理学 

分 类 号：R714.5[医药卫生—妇产科学]