A Golden Touch in the Design of Multifunctional Porphyrin Metallacages:Host-Guest Chemistry for Drug-Target Interactions  

作　　者：Tamara Rodríguez-Prieto Darren Wragg Nicole Heiduk Mihyun Park Nicole Strittmatter Roland A.Fischer Angela Casini Guillermo Moreno-Alcántar 

机构地区：[1]Chair of Medicinal and Bioinorganic Chemistry,Department of Chemistry,School of Natural Sciences,Technical University of Munich,85748 Garching b.München [2]Professorship for Analytical Chemistry,Department of Chemistry,School of Natural Sciences,Technical University of Munich,85748 Garching b.München [3]Chair of Inorganic and MetalOrganic Chemistry,Department of Chemistry,School of Natural Sciences,Technical University of Munich,85748 Garching b.München [4]Munich Data Science Institute(MDSI),Technical University of Munich,85748 Garching b.München

出　　处：《CCS Chemistry》2024年第7期1662-1671,共10页中国化学会会刊（英文）

摘　　要：The use of three-dimensional self-assembled metallacages(MCgs)as multimodal drug platforms holds great promise.However,the synthesis of MCgs with increased complexity and functionality is a great challenge since understanding of the interaction of MCgs with biological targets is still limited.In this context,this work reports on the integration of a gold(III)porphyrin scaffold into a prismatic MCg structure and explores its application for multimodal therapy of cancer in vitro,namely enabling both photodynamic therapy and chemotherapy.Combining experimental approaches with a state-of-the-art metadynamics theoretical study,we discovered that the gold cage shows unprecedented host-guest interaction-driven selective stabilization of guanine-quadruplex(G4)structures-validated anticancer drug targets-disclosing a new mechanism to pursue in the design of supramolecular drugs.

关 键 词：gold metallacages PORPHYRINS G4stabili-zation host-guestchemistry anticanceragents 

分 类 号：O62[理学—有机化学]