Anti-Inflammatory Glycosaminoglycan Oligosaccharides from Colwellia psychrerythraea 34H Capsule:Synthesis and Biological Evaluation  

作　　者：Zhongtang Li Xiaoyu Sun Yuchao Wang Ao Sun Linbo Fu Tongtong Geng Zihui Zhang Ximin Lv Qian Wang Jing Wang Baodi Gou Xiangbao Meng Zhongjun Li 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191

出　　处：《CCS Chemistry》2024年第7期1698-1711,共14页中国化学会会刊（英文）

基　　金：financially supported by the National Natural Science Foundation of China (grant nos.82151223,81930097,and 21977005);the National Key R&D Program of China (grant nos.2022YFF1203005 and 2022YFC2303700).

摘　　要：Capsular polysaccharides(CPS)of Colwellia psychrerythraea 34H consist of linear tetrasaccharides repeating units in a glycosaminoglycan-like fashion.Their biological function is likely involved in the cold adaptation of microbial organisms.The low availability of these glycosaminoglycan structures greatly limits the study of their functions and biological activities.Here,an efficient semisynthetic strategy for CPS tetrasaccharide derivatives is achieved by using disaccharide units degraded from hyaluronic acids.This new synthetic process is suitable for largescale preparation,and several rare tetrasaccharide derivatives containing GalA-GalNAc were readily obtained in high yields.Biological evaluation of their anti-inflammatory effects demonstrated that these CPS tetrasaccharides effectively attenuated the lipopolysaccharide-induced sepsis and acute lung injury by decreasing macrophage infiltration and secretion of microphage-related cytokines in mice.All these results suggest that this new type of CPS tetrasaccharide can be developed as an anti-inflammation agent.

关 键 词：GLYCOSAMINOGLYCAN OLIGOSACCHARIDE GLYCOSYLATION anti-inflammatory agent acute lung injury 

分 类 号：O62[理学—有机化学]