Catalyst-free electrochemical dearomatization of pyridine derivatives  

作　　者：Kui Wang Yingjun Tian Baoying Li Ling Wang Wei Gao Xiaofei Jia Ruiming Wang Yanping Zhu Jianbin Chen 

机构地区：[1]Chen Shandong Provincial Key Laboratory of Molecular Engineering,State Key Laboratory of Biobased Material and Green Papermaking,School of Chemistry and Chemical Engineering,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250353,China [2]Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science,MOE,College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao 266042,China [3]State Key Laboratory of Biobased Material and Green Papermaking,School of Bioengineering,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250353,China [4]School of Pharmacy,Key Laboratory of Molecular Pharmacology and Drug Evaluation,Ministry of Education,Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong,Yantai University,Yantai 264005,China

出　　处：《Green Synthesis and Catalysis》2024年第2期136-139,共4页绿色合成与催化（英文）

基　　金：the National Natural Science Foundation of China(Nos.22171154 and 21801144);the Youth Innovative Talents Recruitment and Cultivation Program of Shandong Higher Education,the Natural Science Foundation of Shandong Province(Nos.ZR2020QB114 and ZR2020QB008);Jinan Science&Technology Bureau(No.2021GXRC080);supported by the Foundation(No.ZZ20190312)of State Key Laboratory of Biobased Material and Green Papermaking,Qilu University of Technology(Shandong Academy of Sciences);the Program for Scientific Research Innovation Team in Colleges and Universities of Shandong Province,the Open Fund of the Department of Chemistry,Qingdao University of Science and Technology(No.QUSTHX202010);Science and Technology Innovation Development Plan of Yantai(No.2020MSGY114);Yantai“Double Hundred Plan”.

摘　　要：We demonstrated herein an electrochemical dearomatizative alkylation of Katritzky salts,wherein Katritzky salts were harnessed as both radical acceptors and donors.A wide range of privileged dihydropyridine scaffolds was constructed with good to excellent yields.Cyclic voltammetry(CV)and electron paramagnetic resonance(EPR)results confirmed the key intermediates-dihydropyridine radicals and gram-scale reaction highlighted the practical and sustainable feature of the newly developed protocol.

关 键 词：DEAROMATIZATION ELECTROSYNTHESIS Katritzky salts Dihydropyridine 

分 类 号：O62[理学—有机化学]