血清AFP、β-hCG、uE3联合miR-146a-5p检测对孕中期唐氏综合征的筛查价值分析  

Serum AFPβ-Analysis of the Screening Value of hCG,uE3 Combined with miR-146a-5p Detection For Down's Syndrome in Mid Pregnancy

作　　者：龚茜倩 Gong Qianqian(Henan Xinyang Central Hospital,He Nan 464000,China)

机构地区：[1]河南省信阳市中心医院,河南信阳464000

出　　处：《哈尔滨医药》2024年第3期14-16,共3页Harbin Medical Journal

摘　　要：目的分析甲胎蛋白(AFP)、β-人绒毛膜促性腺激素(β-hCG)、游离雌三醇(uE3)、微小RNA-146a-5p(miR-146a-5p)联合筛查孕中期唐氏综合征的效果。方法将行唐氏综合征筛查结果为阳性的孕中期孕妇53例纳入观察组,另把同时进行体检的健康孕中期孕妇64例纳入对照组,采集两组入院时的静脉血,检测对比其AFP、β-hCG、uE3、miR-146a-5p差异;另描绘受试者工作曲线(ROC),分析AFP、β-hCG、uE3、miR-146a-5p联合检测筛查唐氏综合征的效果。结果观察组AFP为(20.53±2.81)μg/L、uE3为(1.46±0.34)ng/mL,低于对照组的(46.79±4.57)μg/L,(3.49±0.50)ng/mL,β-hCG为(6.77±1.54)μg/L、miR-146a-5p为(3.24±0.67),高于对照组的(3.15±0.63)μg/L、(1.25±0.31),差异有统计学意义(P<0.05);ROC结果显示:AFP、β-hCG、uE3、miR-146a-5p联合检测筛查唐氏综合征的曲线下面积(AUC)为0.907(95%CI:0.848~0.967),高于单独筛查的0.740(95%CI:0.650~0.830)、0.844(95%CI:0.767~0.921)、0.822(95%CI:0.746-0.899)、0.839(95%CI:0.754~0.923)。结论AFP、β-hCG、uE3联合miR-146a-5p能够有效筛查出孕中期唐氏综合征,有较高的价值。Objective To analyze alpha fetoprotein(AFP)β-Human ch orionic gonadotropin(β-HCG),free Estriol(uE3)and microRNA-146a-5p(miR-146a-5p)were used to screen Down's syndrome in the second trimester of pregnancy.Methods 53 pregnant women in the second trimester with positive results of Down's syndrome screening were divided into the observation group,and 64 healthy pregnant women in the second trimester who underwent physical examination at the same time were divided into the control groupβ-HCG,uE3,miR-146a-5p differences;Draw the receiver operating curve(ROC)and analyze the effectiveness of combined detection of AFP,β-hCG,uE3,and miR-146a-5p in screening for Down's syndrome.Results showed that the AFP and uE3 levels in the observation group were(20.53±2.81)μg/L and(1.46±0.34)ng/mL,respectively,lower than those in the control group(46.79±4.57)μg/L and(3.49±0.50)ng/mL,Theβ-hCG was(6.77±1.54)μg/L,and the miR-146a-5p was(3.24±0.67),which was higher than the control group(3.15±0.63)μg/L and(1.25±0.31),with a statistical difference(P<0.05);ROC results display:The area under the curve(AUC)of AFP,β-hCG,uE3,and miR-146a-5p combined detection for Down's syndrome was 0.907(95%CI:0.848-0.967),which was higher than the screened separately 0.740(95%CI:0.650-0.830),0.844(95%CI:0.767-0.921),0.822(95%CI:0.746-0.899),and 0.839(95%CI:0.754-0.923).Conclusion The combination of AFP,β-hCG,uE3,and miR-146a-5p can effectively screen for Down's syndrome in mid pregnancy,and has high practical value.

关 键 词：唐氏综合征 孕中期 甲胎蛋白 Β-人绒毛膜促性腺激素 

分 类 号：R715.3[医药卫生—妇产科学]