中医治疗慢性萎缩性胃炎的实验机制研究进展  

Research progress on experimental mechanism of traditional Chinese medicine treatment of chronic atrophic gastritis

作　　者：索卓群 李慧臻[2] 马佳乐 赵双梅(审校)[2] SUO Zhuoqun;LI Huizhen;MA Jiale;ZHAO Shuangmei(Tianjin University of Traditional Chinese Medicine,Tianjin,301617,China;Department of Gastroenterology,the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine)

机构地区：[1]天津中医药大学,天津301617 [2]天津中医药大学第二附属医院消化科

出　　处：《中国中西医结合消化杂志》2024年第7期627-631,638,共6页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：国家自然科学基金面上项目(No:82274442)。

摘　　要：慢性萎缩性胃炎(CAG)是消化系统疾病中的常见病,具有病程长、频反复、难治愈、易癌变的特点。目前其发病机制尚不明确,西医认为与幽门螺杆菌(Hp)感染、免疫、胆汁及十二指肠液反流、遗传等因素相关,治疗上主要以杀灭Hp、促进胃肠动力、抑制胃酸为主,对于改善症状有一定疗效,但难以逆转病理,阻止炎-癌转化。中医治疗以辨证论治为基础,通过中药、针灸等治疗方式,在治疗CAG的过程中显示出了极大的优势。本文通过对中医治疗CAG的相关实验研究文献整理发现,中医在减轻CAG炎症反应、修复受损胃黏膜、阻断胃黏膜炎-癌转化等方面疗效极佳,这主要与中药、针灸等有效改善炎症微环境、调节程序性死亡、抗氧化应激、修复胃黏膜损伤、改善胃黏膜代谢及调控胃肠激素释放等6个方面相关,本文现从以上方面进行归纳总结,以期为中医治疗CAG相关机制进展的研究提供参考。Chronic atrophic gastritis(CAG)is a common disease of digestive system,which has the characteristics of long course,frequent recurrence,difficult to cure and easy to become cancerous.At present,its pathogenesis is not clear,Western medicine believes that it is related to Helicobacter pylori(Hp)infection,immunity,bile and duodenal reflux,genetics and other factors.The treatment is mainly to kill Hp,promote gastrointestinal motility,and inhibit gastric acid,which has a certain effect on improving symptoms,but it is difficult to reverse pathology and prevent the transformation of inflammation to cancer.TCM treatment is based on syndrome differentiation and has shown great advantages in the treatment of CAG through TCM,acupuncture and other treatment methods.Through the review of relevant experimental research literature on the treatment of CAG by traditional Chinese medicine,it is found that traditional Chinese medicine has excellent efficacy in alleviating CAG inflammation,repairing damaged gastric mucosa,and blocking the transformation of gastric mucositis to cancer.This is mainly related to the effective improvement of inflammatory microenvironment,regulation of programmed death,anti-oxidative stress,repair of gastric mucosal damage,improvement of gastric mucosal metabolism and regulation of gastrointestinal hormone release by traditional Chinese medicine,acupuncture and moxibustion,etc.This paper summarizes from the above six aspects,in order to provide reference for the research on the progress of relevant mechanisms of TCM treatment of CAG.

关 键 词：慢性萎缩性胃炎 炎-癌转化 中药 针灸 作用机制 

分 类 号：R573.3[医药卫生—消化系统]