CT联合MMP-2、MMP-9、CA19-9对早期结直肠癌T分期的预测价值  

Predictive value of CT combined with MMP-2,MMP-9,CA19-9 in T staging of early colorectal cancer

作　　者：梅建波 滕刚[1] 邹玲 MEI Jianbo;TENG Gang;ZOU Ling(CT Room,People’s Hospital of Macheng City,Macheng 438399,China)

机构地区：[1]湖北省麻城市人民医院CT室,湖北麻城438399

出　　处：《中国中西医结合影像学杂志》2024年第4期449-453,共5页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：2018—2019年度湖北省自然基金面上项目(2019CF B716)。

摘　　要：目的:探讨CT联合血清金属基质蛋白酶2(MMP-2)、金属基质蛋白酶9(MMP-9)、糖类抗原19-9(CA19-9)检测对结直肠癌患者T分期的预测价值。方法:选取结直肠癌患者110例,行CT联合血清MMP-2、MMP-9、CA19-9检测。结果:CT诊断结直肠癌T_(1~2)期、T_(3)期、T_(4)期符合率分别为79.17%(38/48)、84.62%(33/39)、86.96%(20/23),总诊断符合率为82.73%(91/110)。T_(1~2)期、T_(3)期及T_(4)期结直肠癌患者血清MMP-2、MMP-9、CA19-9水平比较差异均有统计学意义(均P<0.05);T_(3)期患者血清MMP-2、MMP-9、CA19-9水平均明显高于T_(1~2)期(均P<0.05);T_(4)期患者血清MMP-2、MMP-9、CA19-9水平均明显高于T_(3)期及T_(1~2)期(均P<0.05)。Spearman相关性分析显示,血清MMP-2、MMP-9、CA19-9水平与结直肠癌T分期呈显著正相关(均P<0.05)。ROC曲线显示,CT联合MMP-2、MMP-9、CA19-9(联合诊断模型)鉴别诊断结直肠癌T_(1~2)期与T_(3)期的AUC明显高于各单项指标(均P<0.05);联合诊断模型鉴别诊断结直肠癌T_(3)期与T_(4)期的AUC明显高于各单项指标(均P<0.05)。结论:CT联合MMP-2、MMP-9、CA19-9检测鉴别诊断结直肠癌T分期具有较高的应用价值。Objective:To investigate the predictive value of CT combined with MMP-2,MMP-9,CA19-9 in T staging of early colorectal cancer.Methods:A total of 110 patients with colorectal cancer were selected to underwent CT scan and serum MMP-2,MMP-9,CA19-9 testing.Results:The coincidence rates of T_(1~2),T_(3) and T_(4) stages diagnosed by CT were 79.17%(38/48),84.62%(33/39)and 86.96%(20/23),respectively,and the total coincidence rate was 82.73%(91/110).The serum levels of MMP-2,MMP-9,CA19-9 in patients with T_(1~2),T_(3) and T_(4) stages colorectal cancer were significantly different(all P<0.05),and the serum levels of MMP-2,MMP-9,CA19-9 in patients with T_(3) stage were significantly higher than those in patients with T_(1~2) stage(all P<0.05),and those in patients with T_(4) stage were significantly higher than those in patients with T_(3) and T_(1~2) stages(all P<0.05).Spearman correlation analysis showed that serum MMP-2,MMP-9,CA19-9 levels were significantly positively correlated with colorectal cancer T staging(all P<0.05).ROC curve showed that AUC of CT combined with MMP-2,MMP-9,CA19-9 for differential diagnosis of colorectal cancer in T_(1~2) and T_(3) stages was significantly higher than that of each single indicator(all P<0.05),and the AUC for differential diagnosis of colorectal cancer in T_(3) and T_(4) stages was also significantly higher than that of each single indicator(all P<0.05).Conclusions:CT combined with MMP-2,MMP-9,CA19-9 has a high application value in differential diagnosis for T staging of colorectal cancer.

关 键 词：结直肠肿瘤 体层摄影术 X线计算机 金属基质蛋白酶-2 金属基质蛋白酶-9 糖类抗原19-9 浸润深度 诊断 

分 类 号：R730.44[医药卫生—肿瘤] R735.34[医药卫生—临床医学]