Complement(ing)the microbiome in infants through breastmilk  

作　　者：Samuel P.Nobs Eran Elinav 

机构地区：[1]Department of Systems Immunology,Weizmann Institute of Science,Rehovot,Israel. [2]Microbiome&Cancer Division,German Cancer Research Center(DKFZ),Heidelberg,Germany.

出　　处：《Cell Research》2024年第7期469-470,共2页细胞研究（英文版）

摘　　要：Breastfeeding has a major impact on the health of infants.In a recent study published in Cell,Xu et al.identify and disentangle a novel molecular role of the maternal complement system in mediating resistance to enteric infection of infants via modulation of their microbiome.The microbiome is considered a critical regulator of health and disease in a growing number of clinical contexts.In particular,the microbiome has been implicated to play a role in mediating development of the immune system in early life.1 Disruption of microbial colonization after birth may predispose to inflammatory diseases in adulthood,including asthma2 and inflammatory bowel disease.3 Multiple factors,including the mode of delivery and breastfeeding,have been suggested to influence development of a healthy microbiome in infancy.4 Indeed,breastmilk plays an important role in protecting the infant from infection by some pathogens such as Helicobacter pylori before the neonatal immune system is fully developed.5 However,the mechanisms by which breastmilk protects the infant from neonatal infection,and whether some of these milk-associated activities involve the gut microbiome,have not been fully defined to date(Fig.1).

关 键 词：BREAST INFECTION 

分 类 号：Q93[生物学—微生物学]