A rare presentation of unicentric Castleman's disease in the thigh:A case report and review of literature  

作　　者：Sultan AlSheikh Abdulmajeed Altoijry Husain Al-Mubarak Ofays Dakkam Alsallum Fadi Alakeel Tariq Alanezi 

机构地区：[1]Division of Vascular Surgery,Department of Surgery,College of Medicine,King Saud University,Riyadh 11322,Saudi Arabia [2]Division of Vascular Surgery,Department of Surgery,King Khalid Hospital Najran,Najran 11321,Saudi Arabia [3]Department of Pathology,College of Medicine,King Saud University,Riyadh 11322,Saudi Arabia

出　　处：《World Journal of Clinical Cases》2024年第19期4003-4009,共7页世界临床病例杂志

摘　　要：BACKGROUND Castleman's disease(CD)is a rare lymphoproliferative,emulating both benign and malignant diseases.The diagnosis of CD is formulated upon the combination of clinical and laboratory criteria and ultimately confirmed by histopathological assessment.Due to its rarity,CD presents a challenge in treatment selection,with available options encompassing surgery,chemotherapy,and autologous stem cell transplantation.However,studies suggest that surgical resection of the lesion is the most effective treatment modality,especially for unicentric CD(UCD).CASE SUMMARY Here,we describe the case of a 25-year-old woman who presented with painless left thigh swelling for 10 wk.She had been following a low-fat diet to lose weight and had normal laboratory results.Magnetic resonance imaging revealed a wellcircumscribed,demarcated cystic lesion located in the left inguinal region with eccentrically positioned signal void vascular structures,measuring 4.3 cm×3 cm×3.2 cm,likely of lymphoid origin.The patient underwent surgical resection,and the final histopathology showed a vascular proliferation and hyalinization of the vessel walls,along with atretic germinal centers traversed by penetrating vessels,consistent with CD.The patient was discharged home one day after the procedure in good condition,with a follow-up appointment scheduled in our outpatient clinic.CONCLUSION Although surgical resection is the mainstay for UCD,a multidisciplinary approach is needed due the lack of specific diagnostic features and treatments.

关 键 词：Castleman’s disease Lymph nodes Surgical resection Lymphoproliferative disorder Case report 

分 类 号：R733[医药卫生—肿瘤]