Metformin administration in prevention of colorectal polyps in type 2 diabetes mellitus patients  

作　　者：Xiao-Qing Wu Li-Hua Deng Qian Xue Xia Li Meng-Han Li Jing-Tong Wang 

机构地区：[1]Department of Geriatrics,Peking University People's Hospital,Beijing 100044,China

出　　处：《World Journal of Clinical Cases》2024年第20期4206-4216,共11页世界临床病例杂志

基　　金：The International Institute of Population Health,Peking University Health Science Center,No.JKCJ202102;The National Key Clinical Specialty Construction Projects,No.2199000764。

摘　　要：BACKGROUND Colorectal polyps are frequently observed in patients with type 2 diabetes mellitus(DM),posing a significant risk for colorectal cancer.Metformin,a widely prescribed biguanidine drug for type 2 DM,has been suggested to have potential chemoprophylactic effects against various cancers.AIM To explore the correlation between colorectal polyps and metformin use in type 2 DM patients.METHODS Type 2 DM patients were categorized into polyp and non-polyp groups.Following this,all patients were categorized into the type 2 DM-metformin,type 2 DM-non-metformin,and non-type 2 DM groups.Based on the baseline colonoscopy results,we performed pairwise comparisons of the incidence of colorectal polyps among the three groups.Additionally,we analyzed the relationship between colorectal polyps and the duration of metformin use and between the size and number of polyps and metformin use.Simultaneously,we focused on the specific pathological types of polyps and analyzed their relationship with metformin use.Finally,we compared the incidence of polyps between metformin and non-metformin groups according to the interval colonoscopy results.RESULTS The rate of metformin use in patients with colorectal polyps was 0.502 times that of patients without colorectal polyps[odds ratio(OR)=0.502,95%confidence interval(CI):0.365-0.689;P<0.001].The incidence of colorectal polyps did not differ significantly between the type 2 DM-metformin and non-type 2 DM groups(P>0.05).Furthermore,the correlations between the duration of metformin use and the incidence of colorectal polyps and between the size and number of polyps and metformin use were not statistically significant(P>0.05).Metformin use did not affect the incidence of colorectal polyps during interval colonoscopy(P>0.05).CONCLUSION Metformin use and colorectal polyp incidence in type 2 DM patients showed a negative correlation,independent of the hypoglycemic effect of metformin.

关 键 词：Colorectal cancer Colorectal polyps Biguanidine drug Diabetes mellitus METFORMIN 

分 类 号：R587.2[医药卫生—内分泌]