Gastroesophageal signet ring cell carcinoma morbidity and mortality: A retrospective review  

作　　者：Megan Grinlinton Chris Furkert Andrew Maurice Neville Angelo Michael Booth 

机构地区：[1]Department of General Surgery,North Shore Hospital,Auckland 0620,New Zealand [2]Department of Pathology,North Shore Hospital,Auckland 0620,New Zealand

出　　处：《World Journal of Gastrointestinal Surgery》2024年第6期1629-1636,共8页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Upper gastrointestinal(GI)signet ring cell carcinomas(SRCC)confer a poor prognosis.The benefit of operative intervention for this patient group is contro-versial in terms of overall survival.AIM To investigate factors relating to survival in patients with upper GI SRCC.METHODS A retrospective,tertiary,single-centre review of patients who were diagnosed with oesophageal,gastroesophageal junction and gastric SRCC was performed.The primary outcome was to compare mortality of patients who underwent operative management with those who had nonoperative management.Secon-dary outcomes included assessing the relationship between demographic and histopathological factors,and survival.RESULTS One hundred and thirty-one patients were included.The one-year survival for the operative group was 81%and for the nonoperative group was 19.1%.The five-year survival in the operative group was 28.6%vs 1.5%in the nonoperative group.The difference in overall survival between groups was statistically significant(HR 0.19,95%CI(0.13-0.30),P<0.001).There was no difference in survival when ad-justing for age,smoking status or gender.On multivariate analysis,patients who underwent surgical management,those with a lower stage of disease,and those with a lower Charlson Comorbidity Index(CCI)had significantly improved sur-vival.CONCLUSION Well-selected patients with upper GI SRCC appear to have reasonable medium-term survival following surgery.Offering surgery to a carefully selected patient group may improve the outcome for this disease.

关 键 词：Signet ring cell carcinoma Gastric cancer Oesophageal cancer Poorly cohesive gastric cancer Diffuse gastric cancer 

分 类 号：R735.2[医药卫生—肿瘤]