Clinical study of neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio in hypertriglyceridemia-induced acute pancreatitis and acute biliary pancreatitis with persistent organ failure  

作　　者：Mu-Sen Xu Jia-Le Xu Xin Gao Shao-Jian Mo Jia-Yu Xing Jia-Hang Liu Yan-Zhang Tian Xi-Feng Fu 

机构地区：[1]The Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan 030032,Shanxi Province,China [2]Department of Environmental Health,School of Public Health,Shanxi Medical University,Taiyuan 030032,Shanxi Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第6期1647-1659,共13页世界胃肠外科杂志（英文版）（电子版）

基　　金：Supported by Shanxi Province“136”Revitalization Medical Project Construction Funds,No.2019XY004.

摘　　要：BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various diseases.We categorize acute pancreatitis by etiology into acute biliary pancreatitis(ABP)and hypertriglyceridemia-induced acute pancreatitis(HTGP).AIM To investigate the clinical significance of NLR and PLR in assessing persistent organ failure(POF)in HTGP and ABP.METHODS A total of 1450 patients diagnosed with acute pancreatitis(AP)for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were enrolled.The patients were categorized into two groups according to the etiology of AP:ABP in 530 patients and HTGP in 241 patients.We collected and compared the clinical data of the patients,including NLR,PLR,and AP prognostic scoring systems,within 48 h of hospital admission.RESULTS The NLR(9.1 vs 6.9,P<0.001)and PLR(203.1 vs 160.5,P<0.001)were significantly higher in the ABP group than in the HTGP group.In the HTGP group,both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score≥3.Likewise,in the ABP group,NLR and PLR were significantly elevated in patients with severe AP,modified computed tomography severity index score≥4,Japanese Severity Score≥3,and modified Marshall score≥2.Moreover,NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP groups.CONCLUSION NLR and PLR vary between ABP and HTGP,are strongly associated with AP prognostic scoring systems,and have predictive potential for the occurrence of POF in both ABP and HTGP.

关 键 词：Acute pancreatitis GALLSTONE HYPERTRIGLYCERIDEMIA Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Persistent organ failure 

分 类 号：R576[医药卫生—消化系统]