Prediction and analysis of albumin-bilirubin score combined with liver function index and carcinoembryonic antigen on liver metastasis of colorectal cancer  

作　　者：Zhan-Mei Wang Shu-Ping Pan Jing-Jing Zhang Jun Zhou 

机构地区：[1]Department of Medical Oncology,Qilu Hospital(Qingdao),Cheeloo College Medicine,Shandong University,Qingdao 266000,Shandong Province,China [2]Department of Gastroenterology,Feicheng People’s Hospital,Feicheng 271600,Shandong Province,China [3]Department of Anus and Intestine Surgery,Xiangya Hospital of Central South University,Changsha 410008,Hunan Province,China [4]Department of Oncology,Qilu Hospital(Qingdao),Cheeloo College Medicine,Shandong University,Qingdao 266000,Shandong Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第6期1670-1680,共11页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Colorectal cancer(CRC)is a common malignant tumor,and liver metastasis is one of the main recurrence and metastasis modes that seriously affect patients’survival rate and quality of life.Indicators such as albumin bilirubin(ALBI)score,liver function index,and carcinoembryonic antigen(CEA)have shown some potential in the prediction of liver metastasis but have not been fully explored.AIM To evaluate its predictive value for liver metastasis of CRC by conducting the combined analysis of ALBI,liver function index,and CEA,and to provide a more accurate liver metastasis risk assessment tool for clinical treatment guidance.METHODS This study retrospectively analyzed the clinical data of patients with CRC who received surgical treatment in our hospital from January 2018 to July 2023 and were followed up for 24 months.According to the follow-up results,the enrolled patients were divided into a liver metastasis group and a nonliver metastasis group and randomly divided into a modeling group and a verification group at a ratio of 2:1.The risk factors for liver metastasis in patients with CRC were analyzed,a prediction model was constructed by least absolute shrinkage and selection operator(LASSO)logistic regression,internal validation was performed by the bootstrap method,the reliability of the prediction model was evaluated by subject-work characteristic curves,calibration curves,and clinical decision curves,and a column graph was drawn to show the prediction results.RESULTS Of 130 patients were enrolled in the modeling group and 65 patients were enrolled in the verification group out of the 195 patients with CRC who fulfilled the inclusion and exclusion criteria.Through LASSO regression variable screening and logistic regression analysis.The ALBI score,alanine aminotransferase(ALT),and CEA were found to be independent predictors of liver metastases in CRC patients[odds ratio(OR)=8.062,95%confidence interval(CI):2.545-25.540],(OR=1.037,95%CI:1.004-1.071)and(OR=1.025,95%CI:1.008-1.043).The area under the recei

关 键 词：Albumin-bilirubin Carcinoembryonic antigen Colorectal cancer Tumor metastasis Prediction model 

分 类 号：R735.7[医药卫生—肿瘤] R73-37[医药卫生—临床医学]