Eosinophilic solid and cystic renal cell carcinoma with aggressive behavior:Two case reports  

作　　者：Hui-Hui Cao Hong Li Xiao-Hong Guo Zhi-Xing Cao Bo-Hui Zhang 

机构地区：[1]Department of Pathology,Zhuhai People's Hospital(Zhuhai Clinical Medical College of Jinan University),Zhuhai 519000,Guangdong Province,China

出　　处：《World Journal of Clinical Cases》2024年第22期5124-5130,共7页世界临床病例杂志

摘　　要：BACKGROUND Eosinophilic solid and cystic(ESC)renal cell carcinoma(RCC),a unique and emerging subtype of RCC,has an indolent nature;in some rare instances,it may exhibit metastatic potential.Current cases are inadequate to precisely predict the clinical outcome of ESC RCC and determine treatment choices.CASE SUMMARY Herein,we report two patients with ESC RCC.Patient 1 was a young woman with classical pathological characteristics.Patient 2 was a 52-year-old man with multifocal metastases,involving the pulmonary hilar and mediastinal lymph nodes,liver,brain,mesosternum,vertebra,rib,femur,and symphysis pubis.Awareness of ESC RCC,along with its characteristic architecture and immunophenotype,would contribute to making a definitive diagnosis,even on core biopsy samples.CONCLUSION The discovery of ESC RCC molecular signatures may provide new therapeutic strategies in the future.

关 键 词：Eosinophilic solid and cystic renal cell carcinoma Solid and cystic growth pattern CK20 TSC1 mutations TSC2 mutations Case report 

分 类 号：R737.11[医药卫生—肿瘤]